Viral channel proteins in intracellular protein-protein communication: Vpu of HIV-1, E5 of HPV16 and p7 of HCV

Wolfgang B. Fischer; Li Hua Li; Dhani Ram Mahato; Yi Ting Wang; Chin Pei Chen

doi:10.1016/j.bbamem.2013.08.017

Viral channel proteins in intracellular protein-protein communication: Vpu of HIV-1, E5 of HPV16 and p7 of HCV

Wolfgang B. Fischer^*, Li Hua Li, Dhani Ram Mahato, Yi Ting Wang, Chin Pei Chen

^*Corresponding author for this work

Institute of Biophotonics

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Viral channel forming proteins are known for their capability to make the lipid membrane of the host cell and its subcellular compartments permeable to ions and small compounds. There is increasing evidence that some of the representatives of this class of proteins are also strongly interacting with host proteins and the effectiveness of this interaction seems to be high. Interaction of viral channel proteins with host factors has been proposed by bioinformatics approaches and has also been identified experimentally. An overview of the interactions with host proteins is given for Vpu from HIV-1, E5 from HPV-16 and p7 from HCV. This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking.

Original language	English
Pages (from-to)	1113-1121
Number of pages	9
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1838
Issue number	4
DOIs	https://doi.org/10.1016/j.bbamem.2013.08.017
State	Published - Apr 2014

Keywords

E5 of HPV16
p7 of HCV
Viral channel proteins
Viral-host protein-protein interaction
Vpu of HIV-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbamem.2013.08.017

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title = "Viral channel proteins in intracellular protein-protein communication: Vpu of HIV-1, E5 of HPV16 and p7 of HCV",

abstract = "Viral channel forming proteins are known for their capability to make the lipid membrane of the host cell and its subcellular compartments permeable to ions and small compounds. There is increasing evidence that some of the representatives of this class of proteins are also strongly interacting with host proteins and the effectiveness of this interaction seems to be high. Interaction of viral channel proteins with host factors has been proposed by bioinformatics approaches and has also been identified experimentally. An overview of the interactions with host proteins is given for Vpu from HIV-1, E5 from HPV-16 and p7 from HCV. This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking.",

keywords = "E5 of HPV16, p7 of HCV, Viral channel proteins, Viral-host protein-protein interaction, Vpu of HIV-1",

author = "Fischer, {Wolfgang B.} and Li, {Li Hua} and Mahato, {Dhani Ram} and Wang, {Yi Ting} and Chen, {Chin Pei}",

note = "Funding Information: WBF acknowledges the support from the National Science Council of Taiwan ( NSC98-2112-M-010-002-MY3 ). RM thanks the Ministry of Education of Taiwan for a fellowship. Helpful and stimulating discussions with Monoj Mon Kalita, Meng-Han Lin, Roman Schilling and Chao-Lung Wang are acknowledged.",

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doi = "10.1016/j.bbamem.2013.08.017",

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AU - Fischer, Wolfgang B.

AU - Li, Li Hua

AU - Mahato, Dhani Ram

AU - Wang, Yi Ting

AU - Chen, Chin Pei

N1 - Funding Information: WBF acknowledges the support from the National Science Council of Taiwan ( NSC98-2112-M-010-002-MY3 ). RM thanks the Ministry of Education of Taiwan for a fellowship. Helpful and stimulating discussions with Monoj Mon Kalita, Meng-Han Lin, Roman Schilling and Chao-Lung Wang are acknowledged.

PY - 2014/4

Y1 - 2014/4

N2 - Viral channel forming proteins are known for their capability to make the lipid membrane of the host cell and its subcellular compartments permeable to ions and small compounds. There is increasing evidence that some of the representatives of this class of proteins are also strongly interacting with host proteins and the effectiveness of this interaction seems to be high. Interaction of viral channel proteins with host factors has been proposed by bioinformatics approaches and has also been identified experimentally. An overview of the interactions with host proteins is given for Vpu from HIV-1, E5 from HPV-16 and p7 from HCV. This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking.

AB - Viral channel forming proteins are known for their capability to make the lipid membrane of the host cell and its subcellular compartments permeable to ions and small compounds. There is increasing evidence that some of the representatives of this class of proteins are also strongly interacting with host proteins and the effectiveness of this interaction seems to be high. Interaction of viral channel proteins with host factors has been proposed by bioinformatics approaches and has also been identified experimentally. An overview of the interactions with host proteins is given for Vpu from HIV-1, E5 from HPV-16 and p7 from HCV. This article is part of a Special Issue entitled: Viral Membrane Proteins - Channels for Cellular Networking.

KW - E5 of HPV16

KW - p7 of HCV

KW - Viral channel proteins

KW - Viral-host protein-protein interaction

KW - Vpu of HIV-1

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U2 - 10.1016/j.bbamem.2013.08.017

DO - 10.1016/j.bbamem.2013.08.017

M3 - Review article

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AN - SCOPUS:84895553393

SN - 0005-2736

VL - 1838

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JO - Biochimica et Biophysica Acta - Biomembranes

JF - Biochimica et Biophysica Acta - Biomembranes

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ER -

Viral channel proteins in intracellular protein-protein communication: Vpu of HIV-1, E5 of HPV16 and p7 of HCV

Abstract

Keywords

UN SDGs

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