Variations in mortality rates among Canadian neonatal intensive care units

Koravangattu Sankaran, Li Yin Chien, Robin Walker, Mary Seshia, Arne Ohlsson, Shoo K. Lee*, Wayne Andrews, Charles A. Janeway, Ranjit Baboolal, Jill Boulton, David Brabyn, David S.C. Lee, Derek Matthew, Douglas D. McMillan, Christine Newman, Abraham Peliowski, Margaret Pendray, Barbara Schmidt, Anne Synnes, Paul ThiessenRobin Whyte, Joanna Sale, Herbert Chan, Shawn Stewart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


Background: Most previous reports of variations in mortality rates for infants admitted to neonatal intensive care units (NICUs) have involved small groups of sub-populations, such as infants with very low birth weight. Our aim was to examine the incidence and causes of death and the risk-adjusted variation in mortality rates for a large group of infants of all birth weights admitted to Canadian NICUs. Methods: We examined the deaths that occurred among all 19 265 infants admitted to 17 tertiary-level Canadian NICUs from January 1996 to October 1997. We used multivariate analysis to examine the risk factors associated with death and the variations in mortality rates, adjusting for risks in the baseline population, severity of illness on admission and whether the infant was outborn (born at a different hospital from the one where the NICU was located). Results: The overall mortality rate was 4% (795 infants died). Forty percent of the deaths (n = 318) occurred within 2 days of NICU admission, 50% (n = 397) within 3 days and 75% (n = 596) within 12 days. The major conditions associated with death were gestational age less than 24 weeks (59 deaths [7%]), gestational age 24-28 weeks (325 deaths [41%]), outborn status (340 deaths [42%]), congenital anomalies (270 deaths [34%]), surgery (141 deaths [18%]), infection (108 deaths [14%]), hypoxic-ischemic encephalopathy (128 deaths [16%]) and small for gestational age (i.e., less than the third percentile) (77 deaths [10%]). There was significant variation in the risk-adjusted mortality rates (range 1.6% to 5.5%) among the 17 NICUs. Interpretation: Most NICU deaths occurred within the first few days after admission. Preterm birth, outborn status and congenital anomalies were the conditions most frequently associated with death in the NICU. The significant variation in risk-adjusted mortality rates emphasizes the importance of risk adjustment for valid comparison of NICU outcomes.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
Issue number2
StatePublished - Jan 2002


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