Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction

Yun Ting Chao; Tzu Yi Hong; Ching Ju Yang; Jen Chuen Hsieh

doi:10.1038/s41598-022-24365-5

Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction

Yun Ting Chao, Tzu Yi Hong, Ching Ju Yang, Jen Chuen Hsieh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The neurogenetic basis of variability in human olfactory function remains elusive. This study examined olfactory performance and resting-state functional neuroimaging results from healthy volunteers within the context of the brain-derived neurotrophic factor (BDNF) val66met polymorphism with the aim of unraveling the genotype-associated intrinsic reorganization of the olfactory network. We found that the presence of the Met allele is associated with better olfactory identification and additional engagement of semantic memory system within the olfactory network, in an allele dosage-dependent manner. This suggests that the Met allele may promote adaptive neural reorganization to augment olfactory capacity.

Original language	English
Article number	20007
Journal	Scientific reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-24365-5
State	Published - Dec 2022

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abstract = "The neurogenetic basis of variability in human olfactory function remains elusive. This study examined olfactory performance and resting-state functional neuroimaging results from healthy volunteers within the context of the brain-derived neurotrophic factor (BDNF) val66met polymorphism with the aim of unraveling the genotype-associated intrinsic reorganization of the olfactory network. We found that the presence of the Met allele is associated with better olfactory identification and additional engagement of semantic memory system within the olfactory network, in an allele dosage-dependent manner. This suggests that the Met allele may promote adaptive neural reorganization to augment olfactory capacity.",

author = "Chao, {Yun Ting} and Hong, {Tzu Yi} and Yang, {Ching Ju} and Hsieh, {Jen Chuen}",

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AU - Hsieh, Jen Chuen

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Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction

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