Use of methylene blue as a diagnostic aid in early detection of oral cancer and precancerous lesions

Ya Wei Chen; Jiun Sheng Lin; Jenny Hwai Jen Fong; I. Kai Wang; Shen Ju Chou; Chen Hsian Wu; Man Tin Lui; Che Shoa Chang; Shou Yen Kao

doi:10.1016/j.bjoms.2006.08.017

Use of methylene blue as a diagnostic aid in early detection of oral cancer and precancerous lesions

Ya Wei Chen, Jiun Sheng Lin, Jenny Hwai Jen Fong, I. Kai Wang, Shen Ju Chou, Chen Hsian Wu, Man Tin Lui, Che Shoa Chang, Shou Yen Kao^*

^*Corresponding author for this work

Department of Dentistry

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We assessed the sensitivity, specificity, and positive and negative predictive value of methylene blue staining in the diagnosis of oral cancer in 58 patients. The sensitivity was 90%, the specificity 69%, positive predictive value 74%, and negative predictive value 87%. Because of the number of false negatives and false positives we recommend that the diagnosis should always be confirmed by histopathological examination of a biopsy specimen. Methylene blue staining may, however, be useful as a screening tool for oral cancer in large, high-risk groups in a similar way to the more expensive toluidine blue.

Original language	English
Pages (from-to)	590-591
Number of pages	2
Journal	British Journal of Oral and Maxillofacial Surgery
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.bjoms.2006.08.017
State	Published - Oct 2007

Keywords

Methylene blue
Oral cancer
Oral precancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bjoms.2006.08.017

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title = "Use of methylene blue as a diagnostic aid in early detection of oral cancer and precancerous lesions",

abstract = "We assessed the sensitivity, specificity, and positive and negative predictive value of methylene blue staining in the diagnosis of oral cancer in 58 patients. The sensitivity was 90%, the specificity 69%, positive predictive value 74%, and negative predictive value 87%. Because of the number of false negatives and false positives we recommend that the diagnosis should always be confirmed by histopathological examination of a biopsy specimen. Methylene blue staining may, however, be useful as a screening tool for oral cancer in large, high-risk groups in a similar way to the more expensive toluidine blue.",

keywords = "Methylene blue, Oral cancer, Oral precancer",

author = "Chen, {Ya Wei} and Lin, {Jiun Sheng} and Fong, {Jenny Hwai Jen} and Wang, {I. Kai} and Chou, {Shen Ju} and Wu, {Chen Hsian} and Lui, {Man Tin} and Chang, {Che Shoa} and Kao, {Shou Yen}",

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T1 - Use of methylene blue as a diagnostic aid in early detection of oral cancer and precancerous lesions

AU - Chen, Ya Wei

AU - Lin, Jiun Sheng

AU - Fong, Jenny Hwai Jen

AU - Wang, I. Kai

AU - Chou, Shen Ju

AU - Wu, Chen Hsian

AU - Lui, Man Tin

AU - Chang, Che Shoa

AU - Kao, Shou Yen

PY - 2007/10

Y1 - 2007/10

N2 - We assessed the sensitivity, specificity, and positive and negative predictive value of methylene blue staining in the diagnosis of oral cancer in 58 patients. The sensitivity was 90%, the specificity 69%, positive predictive value 74%, and negative predictive value 87%. Because of the number of false negatives and false positives we recommend that the diagnosis should always be confirmed by histopathological examination of a biopsy specimen. Methylene blue staining may, however, be useful as a screening tool for oral cancer in large, high-risk groups in a similar way to the more expensive toluidine blue.

AB - We assessed the sensitivity, specificity, and positive and negative predictive value of methylene blue staining in the diagnosis of oral cancer in 58 patients. The sensitivity was 90%, the specificity 69%, positive predictive value 74%, and negative predictive value 87%. Because of the number of false negatives and false positives we recommend that the diagnosis should always be confirmed by histopathological examination of a biopsy specimen. Methylene blue staining may, however, be useful as a screening tool for oral cancer in large, high-risk groups in a similar way to the more expensive toluidine blue.

KW - Methylene blue

KW - Oral cancer

KW - Oral precancer

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SN - 0266-4356

VL - 45

SP - 590

EP - 591

JO - British Journal of Oral and Maxillofacial Surgery

JF - British Journal of Oral and Maxillofacial Surgery

IS - 7

ER -

Use of methylene blue as a diagnostic aid in early detection of oral cancer and precancerous lesions

Abstract

Keywords

UN SDGs

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