TY - JOUR
T1 - Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial—First progress report
AU - the UPRIGHT-HTM Investigators
AU - Chori, Babangida S.
AU - An, De Wei
AU - Martens, Dries S.
AU - Yu, Yu Ling
AU - Gilis-Malinowska, Natasza
AU - Abubakar, Sani M.
AU - Ibrahim, Etubi A.
AU - Ajanya, Ojonojima
AU - Abiodun, Olugbenga O.
AU - Anya, Tina
AU - Tobechukwu, Iyidobi
AU - Isiguzo, Godsent
AU - Cheng, Hao Min
AU - Chen, Chen Huan
AU - Liao, Chia Te
AU - Mokwatsi, Gontse
AU - Stolarz-Skrzypek, Katarzyna
AU - Wojciechowska, Wiktoria
AU - Narkiewicz, Krzysztof
AU - Rajzer, Marek
AU - Brguljan-Hitij, Jana
AU - Nawrot, Tim S.
AU - Asayama, Kei
AU - Reyskens, Peter
AU - Mischak, Harald
AU - Odili, Augustine N.
AU - Staessen, Jan A.
N1 - Publisher Copyright:
© 2023 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.
PY - 2023/6
Y1 - 2023/6
N2 - High blood pressure (BP) and type-2 diabetes (T2DM) are forerunners of chronic kidney disease and left ventricular dysfunction. Home BP telemonitoring (HTM) and urinary peptidomic profiling (UPP) are technologies enabling risk stratification and personalized prevention. UPRIGHT-HTM (NCT04299529) is an investigator-initiated, multicenter, open-label, randomized trial with blinded endpoint evaluation designed to assess the efficacy of HTM plus UPP (experimental group) over HTM alone (control group) in guiding treatment in asymptomatic patients, aged 55–75 years, with ≥5 cardiovascular risk factors. From screening onwards, HTM data can be freely accessed by all patients and their caregivers; UPP results are communicated early during follow-up to patients and caregivers in the intervention group, but at trial closure in the control group. From May 2021 until January 2023, 235 patients were screened, of whom 53 were still progressing through the run-in period and 144 were randomized. Both groups had similar characteristics, including average age (62.0 years) and the proportions of African Blacks (81.9%), White Europeans (16.7%), women 56.2%, home (31.2%), and office (50.0%) hypertension, T2DM (36.4%), micro-albuminuria (29.4%), and ECG (9.7%) and echocardiographic (11.5%) left ventricular hypertrophy. Home and office BP were 128.8/79.2 mm Hg and 137.1/82.7 mm Hg, respectively, resulting in a prevalence of white-coat, masked and sustained hypertension of 40.3%, 11.1%, and 25.7%. HTM persisted after randomization (48 681 readings up to 15 January 2023). In conclusion, results predominantly from low-resource sub-Saharan centers proved the feasibility of this multi-ethnic trial. The COVID-19 pandemic caused delays and differential recruitment rates across centers.
AB - High blood pressure (BP) and type-2 diabetes (T2DM) are forerunners of chronic kidney disease and left ventricular dysfunction. Home BP telemonitoring (HTM) and urinary peptidomic profiling (UPP) are technologies enabling risk stratification and personalized prevention. UPRIGHT-HTM (NCT04299529) is an investigator-initiated, multicenter, open-label, randomized trial with blinded endpoint evaluation designed to assess the efficacy of HTM plus UPP (experimental group) over HTM alone (control group) in guiding treatment in asymptomatic patients, aged 55–75 years, with ≥5 cardiovascular risk factors. From screening onwards, HTM data can be freely accessed by all patients and their caregivers; UPP results are communicated early during follow-up to patients and caregivers in the intervention group, but at trial closure in the control group. From May 2021 until January 2023, 235 patients were screened, of whom 53 were still progressing through the run-in period and 144 were randomized. Both groups had similar characteristics, including average age (62.0 years) and the proportions of African Blacks (81.9%), White Europeans (16.7%), women 56.2%, home (31.2%), and office (50.0%) hypertension, T2DM (36.4%), micro-albuminuria (29.4%), and ECG (9.7%) and echocardiographic (11.5%) left ventricular hypertrophy. Home and office BP were 128.8/79.2 mm Hg and 137.1/82.7 mm Hg, respectively, resulting in a prevalence of white-coat, masked and sustained hypertension of 40.3%, 11.1%, and 25.7%. HTM persisted after randomization (48 681 readings up to 15 January 2023). In conclusion, results predominantly from low-resource sub-Saharan centers proved the feasibility of this multi-ethnic trial. The COVID-19 pandemic caused delays and differential recruitment rates across centers.
KW - chronic kidney disease
KW - home blood pressure telemonitoring
KW - hypertension
KW - left ventricular function
KW - risk factors
KW - type-2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85159006696&partnerID=8YFLogxK
U2 - 10.1111/jch.14664
DO - 10.1111/jch.14664
M3 - Article
C2 - 37147930
AN - SCOPUS:85159006696
SN - 1524-6175
VL - 25
SP - 521
EP - 533
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 6
ER -