TY - JOUR
T1 - Upconversion nanomaterials
T2 - a platform for biosensing, theranostic and photoregulation
AU - Xin, N.
AU - Wei, D.
AU - Zhu, Y.
AU - Yang, M.
AU - Ramakrishna, S.
AU - Lee, O.
AU - Luo, H.
AU - Fan, H.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/9
Y1 - 2020/9
N2 - Upconversion nanoparticles (UCNPs) are a kind of unique optical material, that are able to emit ultraviolet (UV), visible or near infrared (NIR) luminescence upon NIR light excitation. Because of their excellent physic-chemical characters including enormous anti-Stokes spectral shift, high resistance to photobleaching, fairly long luminescent lifetime, excellent chemical stability, sharp emission band, and deep tissue penetration depth, UCNPs have become a useful tool in bioimaging, biosensing, as well as cancer therapy. In particularly, the emissions light from UCNPs can activate photosensitive molecules, which has the potential to realize the regulation of cell behaviors, including cell growth, adhesion and differentiation. This review consequently introduces the principle and achievements of UCNPs in biomedical field to the general readers for promoting both fundamental research and bio-applications of UCNPs. After the brief introduction of the physical mechanism of upconversion luminescence (UCL), we introduce several strategies to enhance the emissions brightness in detail, then discuss various biomedical applications of UCNPs.
AB - Upconversion nanoparticles (UCNPs) are a kind of unique optical material, that are able to emit ultraviolet (UV), visible or near infrared (NIR) luminescence upon NIR light excitation. Because of their excellent physic-chemical characters including enormous anti-Stokes spectral shift, high resistance to photobleaching, fairly long luminescent lifetime, excellent chemical stability, sharp emission band, and deep tissue penetration depth, UCNPs have become a useful tool in bioimaging, biosensing, as well as cancer therapy. In particularly, the emissions light from UCNPs can activate photosensitive molecules, which has the potential to realize the regulation of cell behaviors, including cell growth, adhesion and differentiation. This review consequently introduces the principle and achievements of UCNPs in biomedical field to the general readers for promoting both fundamental research and bio-applications of UCNPs. After the brief introduction of the physical mechanism of upconversion luminescence (UCL), we introduce several strategies to enhance the emissions brightness in detail, then discuss various biomedical applications of UCNPs.
KW - Biomedical applications
KW - Emission optimization
KW - UCL
KW - UCNPs
UR - http://www.scopus.com/inward/record.url?scp=85088103123&partnerID=8YFLogxK
U2 - 10.1016/j.mtchem.2020.100329
DO - 10.1016/j.mtchem.2020.100329
M3 - Review article
AN - SCOPUS:85088103123
SN - 2468-5194
VL - 17
JO - Materials Today Chemistry
JF - Materials Today Chemistry
M1 - 100329
ER -
