Ultrasound ionization of biomolecules

Chen I. Wu; Yi Sheng Wang; G. Chen; Chung Yi Wu; Chung Hsuan Chen

doi:10.1002/rcm.4677

Ultrasound ionization of biomolecules

Chen I. Wu
, Yi Sheng Wang
, G. Chen
, Chung Yi Wu
, Chung Hsuan Chen^*

^*Corresponding author for this work

Department of Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules.

Original language	English
Pages (from-to)	2569-2574
Number of pages	6
Journal	Rapid Communications in Mass Spectrometry
Volume	24
Issue number	17
DOIs	https://doi.org/10.1002/rcm.4677
State	Published - 15 Sep 2010

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10.1002/rcm.4677

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title = "Ultrasound ionization of biomolecules",

abstract = "To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules.",

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AU - Wu, Chen I.

AU - Wang, Yi Sheng

AU - Chen, G.

AU - Wu, Chung Yi

AU - Chen, Chung Hsuan

PY - 2010/9/15

Y1 - 2010/9/15

N2 - To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules.

AB - To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules.

UR - https://www.scopus.com/pages/publications/77955376947

U2 - 10.1002/rcm.4677

DO - 10.1002/rcm.4677

M3 - Article

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AN - SCOPUS:77955376947

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VL - 24

SP - 2569

EP - 2574

JO - Rapid Communications in Mass Spectrometry

JF - Rapid Communications in Mass Spectrometry

IS - 17

ER -

Ultrasound ionization of biomolecules

Abstract

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