Abstract
To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules.
Original language | English |
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Pages (from-to) | 2569-2574 |
Number of pages | 6 |
Journal | Rapid Communications in Mass Spectrometry |
Volume | 24 |
Issue number | 17 |
DOIs | |
State | Published - 15 Sep 2010 |