Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser

Tai Ang Wang; Ming Che Chan; Hsiang Chieh Lee; Cheng Yu Lee; Meng Tsan Tsai

doi:10.1364/BOE.10.005687

Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser

Tai Ang Wang, Ming Che Chan, Hsiang Chieh Lee, Cheng Yu Lee, Meng Tsan Tsai^*

^*Corresponding author for this work

Institute of Photonic System

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based on a spectral-domain detection scheme is constructed, and a spectrometer with a spectral range of 635 − 875 nm is designed. The effective full-width at half maximum of spectrum covers 150 nm, and the corresponding axial and transverse resolutions are 2 and 10 µm in air, respectively. The relative intensity noise of the QS-SCL and mode-locked SCL is quantitatively compared. Furthermore, a special processing algorithm is developed to eliminate the intrinsic noise of QS-SCL. This work demonstrates that QS-SCLs can effectively reduce the cost and size of UHR-OCT/OCTA instruments, making clinical applications feasible.

Original language	English
Pages (from-to)	5687-5702
Number of pages	16
Journal	Biomedical Optics Express
Volume	10
Issue number	11
DOIs	https://doi.org/10.1364/BOE.10.005687
State	Published - Nov 2019

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title = "Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser",

abstract = "In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based on a spectral-domain detection scheme is constructed, and a spectrometer with a spectral range of 635 − 875 nm is designed. The effective full-width at half maximum of spectrum covers 150 nm, and the corresponding axial and transverse resolutions are 2 and 10 µm in air, respectively. The relative intensity noise of the QS-SCL and mode-locked SCL is quantitatively compared. Furthermore, a special processing algorithm is developed to eliminate the intrinsic noise of QS-SCL. This work demonstrates that QS-SCLs can effectively reduce the cost and size of UHR-OCT/OCTA instruments, making clinical applications feasible.",

author = "Wang, {Tai Ang} and Chan, {Ming Che} and Lee, {Hsiang Chieh} and Lee, {Cheng Yu} and Tsai, {Meng Tsan}",

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AU - Tsai, Meng Tsan

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AB - In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based on a spectral-domain detection scheme is constructed, and a spectrometer with a spectral range of 635 − 875 nm is designed. The effective full-width at half maximum of spectrum covers 150 nm, and the corresponding axial and transverse resolutions are 2 and 10 µm in air, respectively. The relative intensity noise of the QS-SCL and mode-locked SCL is quantitatively compared. Furthermore, a special processing algorithm is developed to eliminate the intrinsic noise of QS-SCL. This work demonstrates that QS-SCLs can effectively reduce the cost and size of UHR-OCT/OCTA instruments, making clinical applications feasible.

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Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser

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