Two easy-to-perform diagnostic tests for Gilbert's syndrome

Yen Cheng Chen, Tzeon Jye Chiou*, Muh Hwa Yang, I. Ting Yu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Gilbert's syndrome is a benign, often familial condition characterized by asymptomatic jaundice. A patient suffering from Gilbert's syndrome may have hepatic activity of bilirubin-UDP-glucuronosyltransferase decreasing to levels around 30% of the normal. A clinical diagnosis of Gilbert's syndrome is usually followed in case of mild hyperbilirubinemia with a high fraction of unconjugated bilirubin, normal values of liver enzymes, and no overt signs of hemolysis. This article reported a 17-year-old male with only partial indication of indirect hyperbilirubinemia. Rifampicin test and caloric restriction test were applied to assure the patient had Gilbert's syndrome. These two non-invasive diagnostic means, with the benefit of avoiding hazardous liver biopsy, are gaining popularity in our routine Gilbert's syndrome examination.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalChinese Medical Journal (Taipei)
Issue number5
StatePublished - May 2002


  • Caloric restriction
  • Gilbert's syndrome
  • Rifampicin


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