Treatment for the endocrine resistant breast cancer: Current options and future perspectives

Chun Yu Liu; Chia Yun Wu; Karineh Petrossian; Tzu Ting Huang; Ling Ming Tseng; Shiuan Chen

doi:10.1016/j.jsbmb.2017.07.001

Treatment for the endocrine resistant breast cancer: Current options and future perspectives

Chun Yu Liu, Chia Yun Wu, Karineh Petrossian, Tzu Ting Huang, Ling Ming Tseng, Shiuan Chen^*

^*Corresponding author for this work

Department of Internal Medicine

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Endocrine resistance remains a challenge and an unmet need for managing hormone receptor-positive breast cancer. The mechanisms of endocrine resistance are multifaceted and are likely to evolve over time following various single or combination therapies. The purpose of this review article is to provide general understanding of molecular basis of endocrine resistance of breast cancer and to offer comprehensive review on current treatment options and potential new treatment strategies for endocrine resistant breast cancers. Last but not the least, we discuss current challenges and future directions for management of endocrine resistant breast cancers.

Original language	English
Pages (from-to)	166-175
Number of pages	10
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	172
DOIs	https://doi.org/10.1016/j.jsbmb.2017.07.001
State	Published - Sep 2017

Keywords

Breast cancer
Endocrine resistance
Estrogen receptor
Hormone receptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jsbmb.2017.07.001

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title = "Treatment for the endocrine resistant breast cancer: Current options and future perspectives",

abstract = "Endocrine resistance remains a challenge and an unmet need for managing hormone receptor-positive breast cancer. The mechanisms of endocrine resistance are multifaceted and are likely to evolve over time following various single or combination therapies. The purpose of this review article is to provide general understanding of molecular basis of endocrine resistance of breast cancer and to offer comprehensive review on current treatment options and potential new treatment strategies for endocrine resistant breast cancers. Last but not the least, we discuss current challenges and future directions for management of endocrine resistant breast cancers.",

keywords = "Breast cancer, Endocrine resistance, Estrogen receptor, Hormone receptor",

author = "Liu, {Chun Yu} and Wu, {Chia Yun} and Karineh Petrossian and Huang, {Tzu Ting} and Tseng, {Ling Ming} and Shiuan Chen",

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doi = "10.1016/j.jsbmb.2017.07.001",

language = "English",

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T1 - Treatment for the endocrine resistant breast cancer

T2 - Current options and future perspectives

AU - Liu, Chun Yu

AU - Wu, Chia Yun

AU - Petrossian, Karineh

AU - Huang, Tzu Ting

AU - Tseng, Ling Ming

AU - Chen, Shiuan

PY - 2017/9

Y1 - 2017/9

N2 - Endocrine resistance remains a challenge and an unmet need for managing hormone receptor-positive breast cancer. The mechanisms of endocrine resistance are multifaceted and are likely to evolve over time following various single or combination therapies. The purpose of this review article is to provide general understanding of molecular basis of endocrine resistance of breast cancer and to offer comprehensive review on current treatment options and potential new treatment strategies for endocrine resistant breast cancers. Last but not the least, we discuss current challenges and future directions for management of endocrine resistant breast cancers.

AB - Endocrine resistance remains a challenge and an unmet need for managing hormone receptor-positive breast cancer. The mechanisms of endocrine resistance are multifaceted and are likely to evolve over time following various single or combination therapies. The purpose of this review article is to provide general understanding of molecular basis of endocrine resistance of breast cancer and to offer comprehensive review on current treatment options and potential new treatment strategies for endocrine resistant breast cancers. Last but not the least, we discuss current challenges and future directions for management of endocrine resistant breast cancers.

KW - Breast cancer

KW - Endocrine resistance

KW - Estrogen receptor

KW - Hormone receptor

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U2 - 10.1016/j.jsbmb.2017.07.001

DO - 10.1016/j.jsbmb.2017.07.001

M3 - Review article

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AN - SCOPUS:85022203073

SN - 0960-0760

VL - 172

SP - 166

EP - 175

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

ER -

Treatment for the endocrine resistant breast cancer: Current options and future perspectives

Abstract

Keywords

UN SDGs

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