This work describes a proposed 60-GHz radio-over-fiber (RoF) system employing a frequency sextupling optical up-conversion scheme. Based on the modified single sideband modulation scheme, spectrally efficient vector signals were transmitted with no performance degradation due to dispersion-induced fading. Wavelength-division- multiplexed optical up-conversion can be realized using the proposed system. Since the required transmitter bandwidth is significantly reduced, radio-frequency components with lower bandwidth and higher reliability can be utilized. Both 13.75-Gb/s QPSK-OFDM and 20.625-Gb/s 8QAM-OFDM signals were experimentally demonstrated. After transmission over 25-km of standard single mode fiber, no significant received power penalty was observed.