Transforming growth factor-β1 level and outcome after catheter ablation for nonparoxysmal atrial fibrillation

Cheng Hsueh Wu, Yu Feng Hu, Chia Yu Chou, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Ta Chuan Tuan, Cheng Hung Li, Tze Fan Chao, Fa Po Chung, Jo Nan Liao, Shih Ann Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background: Atrial fibrosis plays a role in the development of a vulnerable substrate for atrial fibrillation (AF). Transforming growth factor (TGF)-β1 is related to the degree of atrial fibrosis and the recurrence of AF after surgical maze procedures. Whether TGF-β1 is associated with the outcome after catheter ablation for AF remains unclear. Objective: The purpose of this study was to investigate whether plasma TGF-β1 was an independent predictor of AF recurrence after catheter ablation. Methods: Two hundred consecutive AF patients (154 with paroxysmal AF and 46 with nonparoxysmal AF) underwent catheter ablation. Their TGF-β1 levels and clinical and echocardiographic data were collected before ablation. Results: Thirty patients (65%) with nonparoxysmal AF and 57 (37%) with paroxysmal AF had AF recurrence after catheter ablation. Among patients with nonparoxysmal AF, those experiencing recurrence had higher TGF-β1 levels than did those who did not experience recurrence (34.63±11.98 ng/mL vs 27.33±9.81 ng/mL; P =.026). In patients with paroxysmal AF, recurrence was not associated with different TGF-β1 levels. In patients with nonparoxysmal AF, TGF-β1 levels and left atrial diameter (LAD) were independent predictors of AF recurrence after catheter ablation. Moreover, TGF-β1 levels had an incremental value over LAD in predicting AF recurrence after catheter ablation (global χ2 of LAD alone: 6.3; LAD and TGF-β1 levels: 11.9; increment in global χ2 = 5.6; P =.013). Patients with small LAD and low TGF-β1 levels had the lowest AF recurrence rate at 11%. Conclusion: TGF-β1 level is an independent predictor of AF recurrence in patients with nonparoxysmal AF and might be useful for identifying those patients likely to have better outcomes after catheter ablation.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalHeart Rhythm
Volume10
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Atrial fibrillation
  • Atrial fibrosis
  • Catheter ablation
  • Transforming growth factor-β

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