Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury

Li Fang Chou; Chih Wei Huang; Huang Yu Yang; Ya Chung Tian; Ming Yang Chang; Cheng Chieh Hung; Kuan Hsing Chen; Shen Hsing Hsu; Chung Ying Tsai; Yi Ching Ko; Ting Wen Chen; Chih Wei Yang

doi:10.1016/j.ygeno.2023.110624

Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury

Li Fang Chou, Chih Wei Huang, Huang Yu Yang, Ya Chung Tian, Ming Yang Chang, Cheng Chieh Hung, Kuan Hsing Chen, Shen Hsing Hsu, Chung Ying Tsai, Yi Ching Ko, Ting Wen Chen^*, Chih Wei Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Leptospirosis can cause chronic kidney damage, putting patients at risk of additional kidney injury due to other factors that can lead to renal failure. To understand the combined effect, the transcriptome profiles of kidneys of mice with adenine-induced and chronically Leptospira-infected kidneys were analysed. Chronic inflammation and T-helper 17 immune responses were activated and a high-level expression of Indoleamine 2,3-dioxygenase 1 protein was found. The results indicate that the combination may predispose patients to chronic inflammation, kidney function disruption, and symptoms seen in progressive chronic kidney disease (CKD). Furthermore, immunometabolic regulation may contribute to renal injury caused by chronic leptospirosis with secondary nephrotoxic injury. This study identified several significantly disrupted genes that could serve as potential targets for the diagnosis or treatment of CKD. Our work provides insight into the combined effect of leptospirosis and secondary kidney damage and the molecular basis for rapid progression of CKD.

Original language	English
Article number	110624
Journal	Genomics
Volume	115
Issue number	3
DOIs	https://doi.org/10.1016/j.ygeno.2023.110624
State	Published - May 2023

Keywords

Adenine
Chronic kidney disease
Combinatory effect
Leptospirosis
Renal transcriptome

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10.1016/j.ygeno.2023.110624

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Chou, L. F., Huang, C. W., Yang, H. Y., Tian, Y. C., Chang, M. Y., Hung, C. C., Chen, K. H., Hsu, S. H., Tsai, C. Y., Ko, Y. C., Chen, T. W., & Yang, C. W. (2023). Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury. Genomics, 115(3), Article 110624. https://doi.org/10.1016/j.ygeno.2023.110624

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title = "Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury",

abstract = "Leptospirosis can cause chronic kidney damage, putting patients at risk of additional kidney injury due to other factors that can lead to renal failure. To understand the combined effect, the transcriptome profiles of kidneys of mice with adenine-induced and chronically Leptospira-infected kidneys were analysed. Chronic inflammation and T-helper 17 immune responses were activated and a high-level expression of Indoleamine 2,3-dioxygenase 1 protein was found. The results indicate that the combination may predispose patients to chronic inflammation, kidney function disruption, and symptoms seen in progressive chronic kidney disease (CKD). Furthermore, immunometabolic regulation may contribute to renal injury caused by chronic leptospirosis with secondary nephrotoxic injury. This study identified several significantly disrupted genes that could serve as potential targets for the diagnosis or treatment of CKD. Our work provides insight into the combined effect of leptospirosis and secondary kidney damage and the molecular basis for rapid progression of CKD.",

keywords = "Adenine, Chronic kidney disease, Combinatory effect, Leptospirosis, Renal transcriptome",

author = "Chou, {Li Fang} and Huang, {Chih Wei} and Yang, {Huang Yu} and Tian, {Ya Chung} and Chang, {Ming Yang} and Hung, {Cheng Chieh} and Chen, {Kuan Hsing} and Hsu, {Shen Hsing} and Tsai, {Chung Ying} and Ko, {Yi Ching} and Chen, {Ting Wen} and Yang, {Chih Wei}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = may,

doi = "10.1016/j.ygeno.2023.110624",

language = "English",

volume = "115",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "3",

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TY - JOUR

T1 - Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury

AU - Chou, Li Fang

AU - Huang, Chih Wei

AU - Yang, Huang Yu

AU - Tian, Ya Chung

AU - Chang, Ming Yang

AU - Hung, Cheng Chieh

AU - Chen, Kuan Hsing

AU - Hsu, Shen Hsing

AU - Tsai, Chung Ying

AU - Ko, Yi Ching

AU - Chen, Ting Wen

AU - Yang, Chih Wei

PY - 2023/5

Y1 - 2023/5

N2 - Leptospirosis can cause chronic kidney damage, putting patients at risk of additional kidney injury due to other factors that can lead to renal failure. To understand the combined effect, the transcriptome profiles of kidneys of mice with adenine-induced and chronically Leptospira-infected kidneys were analysed. Chronic inflammation and T-helper 17 immune responses were activated and a high-level expression of Indoleamine 2,3-dioxygenase 1 protein was found. The results indicate that the combination may predispose patients to chronic inflammation, kidney function disruption, and symptoms seen in progressive chronic kidney disease (CKD). Furthermore, immunometabolic regulation may contribute to renal injury caused by chronic leptospirosis with secondary nephrotoxic injury. This study identified several significantly disrupted genes that could serve as potential targets for the diagnosis or treatment of CKD. Our work provides insight into the combined effect of leptospirosis and secondary kidney damage and the molecular basis for rapid progression of CKD.

AB - Leptospirosis can cause chronic kidney damage, putting patients at risk of additional kidney injury due to other factors that can lead to renal failure. To understand the combined effect, the transcriptome profiles of kidneys of mice with adenine-induced and chronically Leptospira-infected kidneys were analysed. Chronic inflammation and T-helper 17 immune responses were activated and a high-level expression of Indoleamine 2,3-dioxygenase 1 protein was found. The results indicate that the combination may predispose patients to chronic inflammation, kidney function disruption, and symptoms seen in progressive chronic kidney disease (CKD). Furthermore, immunometabolic regulation may contribute to renal injury caused by chronic leptospirosis with secondary nephrotoxic injury. This study identified several significantly disrupted genes that could serve as potential targets for the diagnosis or treatment of CKD. Our work provides insight into the combined effect of leptospirosis and secondary kidney damage and the molecular basis for rapid progression of CKD.

KW - Adenine

KW - Chronic kidney disease

KW - Combinatory effect

KW - Leptospirosis

KW - Renal transcriptome

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DO - 10.1016/j.ygeno.2023.110624

M3 - Article

C2 - 37062365

AN - SCOPUS:85152647789

SN - 0888-7543

VL - 115

JO - Genomics

JF - Genomics

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M1 - 110624

ER -

Transcriptome landscape reveals the chronic inflammatory response in kidneys affected by the combinatory effect of leptospirosis and nephrotoxic injury

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