Traditional herbal medicine mediated regulations during head and neck carcinogenesis

Xiang Yun Lan, Tzu Ting Chung, Chien Ling Huang, Yi Jang Lee, Wan Chun Li*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent neoplasms worldwide. It is well recognized that environmental challenges such as smoking, viral infection and alcohol consumption are key factors underlying HNSCC pathogenesis. Other than major clinical interventions (e.g., surgical resection, chemical and radiotherapy) that have been routinely practiced over years, adjuvant anticancer agents from Traditional Herbal Medicine (THM) are proposed, either alone or together with conventional therapies, to be experimentally effective for improving treatment efficacy in different cancers including HNSCCs. At a cellular and molecular basis, THM extracts could modulate different malignant indices via distinct signaling pathways and provide better control in HNSCC malignancy and its clinical complications such as radiotherapy-induced xerostomia/oral mucositis. In this article, we aim to systemically review the impacts of THM in regulating HNSCC tumorous identities and its potential perspective for clinical use.

Original languageEnglish
Article number1321
Pages (from-to)1-19
Number of pages19
JournalBiomolecules
Volume10
Issue number9
DOIs
StatePublished - Sep 2020

Keywords

  • Angiogenesis
  • Head and neck cancer
  • Integrative therapy
  • Metastasis
  • Oral mucositis
  • Traditional herbal medicine
  • Tumor growth
  • Xerostomia

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