TY - JOUR
T1 - Trabecular bone morphological analysis for preclinical osteoporosis application using micro computed tomography scanner
AU - Jin, David Shih Chun
AU - Chu, Chien Hao
AU - Chen, Jyh Cheng
N1 - Publisher Copyright:
© Taiwanese Society of Biomedical Engineering 2016.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Trabecular bone morphological parameter (TMP) analysis with micro computed tomography (micro-CT) has been used to evaluate the risk of fracture of osteoporosis in small animals. Many researchers have pointed out the drawback of making decisions based on bone mineral density only due to the lack of morphological information. Our study describes the application of a laboratorymicro-CT systemand a self-designed TMP algorithm combined with two statistical methodological tools for the evaluation of the artificially induced animal model by the ovariectomy (OVX) surgery process. The results show that the percentage bone volume (BV/TV), the trabecular properties thickness (TbTh), number (TbN), and separation (TbSp) have significant differences between the normal and OVX groups. TbTh and TbSp had very low p-values and are associated with bone loss caused by osteoporosis. The method can be used to early detect osteoporosis to prevent the risk of fracture in aging small animals.
AB - Trabecular bone morphological parameter (TMP) analysis with micro computed tomography (micro-CT) has been used to evaluate the risk of fracture of osteoporosis in small animals. Many researchers have pointed out the drawback of making decisions based on bone mineral density only due to the lack of morphological information. Our study describes the application of a laboratorymicro-CT systemand a self-designed TMP algorithm combined with two statistical methodological tools for the evaluation of the artificially induced animal model by the ovariectomy (OVX) surgery process. The results show that the percentage bone volume (BV/TV), the trabecular properties thickness (TbTh), number (TbN), and separation (TbSp) have significant differences between the normal and OVX groups. TbTh and TbSp had very low p-values and are associated with bone loss caused by osteoporosis. The method can be used to early detect osteoporosis to prevent the risk of fracture in aging small animals.
KW - Biomedical image analysis
KW - Bone mineral density (BMD)
KW - Osteoporosis
KW - Three-dimensional segmentation
KW - Trabecular bone morphological parameters (TMPs)
UR - http://www.scopus.com/inward/record.url?scp=84960854728&partnerID=8YFLogxK
U2 - 10.1007/s40846-016-0109-0
DO - 10.1007/s40846-016-0109-0
M3 - Article
AN - SCOPUS:84960854728
SN - 1609-0985
VL - 36
SP - 96
EP - 104
JO - Journal of Medical and Biological Engineering
JF - Journal of Medical and Biological Engineering
IS - 1
ER -