Topical sulphamethoxazole ophthalmic solution induced toxic epidermal necrolysis

Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction that leads to widespread mucocutaneous necrosis. Medications are the most common cause of TEN. However, some cases develop following infection or vaccination. TEN is very rarely induced by topical ophthalmic solution or topical agent. We report a case of a 31-year-old female who developed TEN after using topical sulphamethoxazole ophthalmic solution. Skin biopsy was performed and revealed upper epidermal necrosis with cell-poor inflammatory infiltrate. After admission, the patient received systemic and topical corticosteroid, as well as supportive treatment. The prognosis was good at follow-up 21 days later.