Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

Chau Chung Wu; Yih Ming Wang; Long Sheng Lu; Chia-Wei Sun; Chih Wei Lu; Meng Tsan Tsai; C. C. Yang

doi:10.1117/1.2812647

Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

Chau Chung Wu, Yih Ming Wang, Long Sheng Lu, Chia-Wei Sun, Chih Wei Lu, Meng Tsan Tsai, C. C. Yang^*

^*Corresponding author for this work

Department of Photonics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48 ×10^-4 at 790 nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.

Original language	English
Article number	064022
Journal	Journal of Biomedical Optics
Volume	12
Issue number	6
DOIs	https://doi.org/10.1117/1.2812647
State	Published - 1 Nov 2007

Keywords

Liver
Optical coherence tomography
Tissue birefringence

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10.1117/1.2812647

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abstract = "We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48 ×10-4 at 790 nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.",

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AU - Wu, Chau Chung

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AU - Lu, Long Sheng

AU - Sun, Chia-Wei

AU - Lu, Chih Wei

AU - Tsai, Meng Tsan

AU - Yang, C. C.

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AB - We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48 ×10-4 at 790 nm in hypercholesterolemic rat liver. The infiltration of macrophages and increased collagen deposition should be major causes for tissue birefringence in hypercholesterolemic liver.

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Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

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Keywords

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