Tid1 functions as a tumour suppressor in head and neck squamous cell carcinoma

Chi Yuan Chen, Shih Hwa Chiou, Chih Yang Huang, Chia Ing Jan, Shu Chun Lin, Wen Yuan Hu, Shiu Huey Chou, Chung Ji Liu, Jeng Fan Lo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Human tumourous imaginal disc (Tid1), a human homologue of the Drosophila tumour suppressor protein Tid56, is involved in multiple intracellular signalling pathways such as apoptosis, cell proliferation, and cell survival. Here, we investigated the anti-tumourigenic activity of Tid1 in head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo. Firstly, the clinical association between Tid1 expression and progression of HNSCC was explored. It was found that expression of Tid1 was negatively associated with tumour status, recurrence, and survival prognosis using immunohistochemical analysis of primary HNSCC patient tumour tissue. Secondly, ectopic expression of Tid1 in HNSCC cells was shown to significantly inhibit cell proliferation, migration, invasion, anchorage-independent growth, and xenotransplantation tumourigenicity. Thirdly, we showed that overexpression of Tid1 attenuated EGFR activity and blocked the activation of AKT in HNSCC cells, which are known to be involved in the regulation of survival in HNSCC cells. On the other hand, ectopic expression of constitutively active AKT greatly reduced apoptosis induced by Tid1 overexpression. Together, these findings suggest that Tid1 functions as a tumour suppressor in HNSCC tumourigenesis.

Original languageEnglish
Pages (from-to)347-355
Number of pages9
JournalJournal of Pathology
Volume219
Issue number3
DOIs
StatePublished - Nov 2009

Keywords

  • AKT
  • EGFR
  • Head and neck cancer
  • Tid1
  • Tumour suppressor

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