Thy-1 is a component common to multiple populations of synaptic vesicles

Chung Jiuan Jeng, Steven A. McCarroll, Thomas F.J. Martin, Erik Floor, James Adams, David Krantz, Stefan Butz, Robert Edwards, Erik S. Schweitzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Thy-1, a glycosylphosphatidylinositol-linked integral membrane protein of the immunoglobulin superfamily, is a component of both large dense-core and small clear vesicles in PC12 cells. A majority of this protein, formerly recognized only on the plasma membrane of neurons, is localized to regulated secretory vesicles. Thy-1 is also present in synaptic vesicles in rat central nervous system. Experiments on permeabilized PC12 cells demonstrate that antibodies against Thy-1 inhibit the regulated release of neurotransmitter; this inhibition appears to be independent of any effect on the Ca2+ channel. These findings suggest Thy-1 is an integral component of many types of regulated secretory vesicles, and plays an important role in the regulated vesicular release of neurotransmitter at the synapse.

Original languageEnglish
Pages (from-to)685-698
Number of pages14
JournalJournal of Cell Biology
Issue number3
StatePublished - 9 Feb 1998


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