Thermopneumatic suction integrated microfluidic blood analysis system

Chiao Hsun Yang, Yu Ling Hsieh, Ping Hsien Tsou, Bor-Ran Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Blood tests provide crucial diagnostic information regarding several diseases. A key factor that affects the precision and accuracy of blood tests is the interference of red blood cells; however, the conventional methods of blood separation are often complicated and time consuming. In this study, we devised a simple but high-efficiency blood separation system on a self-strained microfluidic device that separates 99.7 ± 0.3% of the plasma in only 6 min. Parameters, such as flow rate, design of the filter trench, and the relative positions of the filter trench and channel, were optimized through microscopic monitoring. Moreover, this air-difference-driven device uses a cost-effective and easy-to-use heater device that creates a low-pressure environment in the microchannel within minutes. With the aforementioned advantages, this blood separation device could be another platform choice for point-of-care testing.

Original languageEnglish
Article numbere0208676
Pages (from-to)1-15
Number of pages15
JournalPLoS ONE
Volume14
Issue number3
DOIs
StatePublished - Mar 2019

Keywords

  • PLASMA SEPARATION; POINT; DIAGNOSTICS; DRIVEN; CANCER; CHIP; BIOSENSORS; PARTICLES; SURFACE; DEVICE

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