Therapeutic time window for rt-PA thrombolysis in a rat photothrombotic ischemic stroke model

Aishwarya Bandla, Ji Min Ling, Yu Hang Liu, Hsin Yi Lai, You Yin Chen, Nitish V. Thakor, Lun De Liao*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

The narrow 3h therapeutic time window for recombinant tissue-type plasminogen activator (rt-PA) thrombolysis is a challenging limitation in acute ischemic stroke treatment. Intense research focus is being laid on developing novel therapeutic interventions for extending the thrombolysis time window using animal stroke models. However, these animal models are anatomically and physiologically different. Here, we assess the effective time window of rt-PA thrombolysis in the photothrombotic ischemic (PTI) stroke model using the electrocorticography (ECoG) system and histology study. Our results indicate that rt-PA provides effective thrombolysis when administered in the initial 1 to 3 hours post-ischemia, beyond which it does not facilitate recovery. This complements the FDA-approved rt-PA time window in humans. However, it is interesting to note that the trend of neural activity did not strictly correspond to infarct volume changes, indicating the importance of multimodal imaging for holistic assessment of therapeutic efficacy. Therefore, in the future, this ECoG setup will be integrated with the functional photoacoustic microscopy (fPAM) system to jointly evaluate neural activity and cerebral hemodynamics to probe neurovascular function changes effective with thrombolysis.

Original languageEnglish
Title of host publication1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
EditorsFong-Chin Su, Ming-Long Yeh, Shyh-Hau Wang
PublisherSpringer Verlag
Pages231-234
Number of pages4
ISBN (Electronic)9783319122618
DOIs
StatePublished - 2015
Event1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
Duration: 9 Oct 201412 Oct 2014

Publication series

NameIFMBE Proceedings
Volume47
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Conference

Conference1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
Country/TerritoryTaiwan
CityTainan
Period9/10/1412/10/14

Keywords

  • Acute ischemic stroke
  • Electrocorticography (ECoG)
  • Photothrombotic ischemia (PTI)
  • Recombinant tissue-type plasminogen activator (rt-PA)
  • Thrombolysis time window

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