Therapeutic target identification for lung cancer

Chien Hung Huang, Min You Wu, Chi-Ying Huang, Ka Lok Ng*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


It is known that the cause of cancer could be due to the gain of function of an oncoprotein (OCP) or the lost of function of a tumor suppressor protein (TSP). These proteins are potential targets for drugs. Lung cancer is one of the leading causes of death in Taiwan. In this study, differential expressed genes (DEGs) are identified, using the Bioconductor package, via expression dataset generated from human lung adenocarcinoma tumor and adjacent non-tumor tissues. By integrating complementary resources, that is, microarray (ArrayExpress), protein-protein interaction (BioGrid), and protein complex (MIPS); it is found that certain cancer-related DEGs match with known protein complexes. After constructing the lung cancer protein-protein interaction network (PPIN), we performed graph theory analysis of PPIN. Highly dense modules (k-clique communities) are identified, which are potential cancer-related protein complexes. Up-clique and down-clique genes were used as queries to perform functional annotation clustering on DAVID. Over-represented or enriched biological processes and pathways are determined. Our findings suggest a potential relationship between those processes (as well as pathways) and cancer, which deserve further drug-gene interaction and potential drugs investigation.

Original languageEnglish
Title of host publicationProceedings of the International MultiConference of Engineers and Computer Scientists 2013, IMECS 2013
PublisherNewswood Limited
Number of pages4
ISBN (Print)9789881925183
StatePublished - 13 Mar 2013
EventInternational MultiConference of Engineers and Computer Scientists 2013, IMECS 2013 - Kowloon, Hong Kong
Duration: 13 Mar 201315 Mar 2013

Publication series

NameLecture Notes in Engineering and Computer Science
ISSN (Print)2078-0958


ConferenceInternational MultiConference of Engineers and Computer Scientists 2013, IMECS 2013
Country/TerritoryHong Kong


  • Enrichment analysis
  • Lung cancer
  • Microarray data analysis
  • Protein complexes
  • Protein-protein interactions


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