Therapeutic implications of cortical spreading depression models in migraine

Tsubasa Takizawa, Cenk Ayata, Shih Pin Chen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations


Migraine is among the most common and disabling neurological diseases in the world. Cortical spreading depression (CSD) is a wave of near-complete depolarization of neurons and glial cells that slowly propagates along the cortex creating the perception of aura. Evidence suggests that CSD can trigger migraine headache. Experimental models of CSD have been considered highly translational as they recapitulate migraine-related phenomena and have been validated for screening migraine therapeutics. Here we outline the essential components of validated experimental models of CSD and provide a comprehensive review of potential modulators and targets against CSD. We further focus on novel interventions that have been recently shown to suppress CSD susceptibility that may lead to therapeutic targets in migraine.

Original languageEnglish
Title of host publicationUpdate on Emerging Treatments for Migraine
EditorsShuu-Jiun Wang, Shuu-Jiun Wang, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau
PublisherElsevier B.V.
Number of pages39
ISBN (Print)9780128211083
StatePublished - 2020

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855


  • ASIC channel
  • Aura
  • Cortical spreading depolarization
  • Cortical spreading depression
  • Migraine
  • P2X7
  • Pannnexin-1
  • Susceptibility
  • TRP channels
  • Transcranial magnetic stimulation
  • Vagus nerve stimulation


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