The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs

Yen Jen Wang; Mikael Larsson; Wei Ting Huang; Shih Hwa Chiou; Stephen J. Nicholls; Jui-I Chao; Dean-Mo LIu

doi:10.1016/j.progpolymsci.2016.01.002

The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs

Yen Jen Wang, Mikael Larsson, Wei Ting Huang, Shih Hwa Chiou, Stephen J. Nicholls, Jui-I Chao, Dean-Mo LIu^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the possibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy.

Original language	English
Pages (from-to)	153-178
Number of pages	26
Journal	Progress in Polymer Science
Volume	57
DOIs	https://doi.org/10.1016/j.progpolymsci.2016.01.002
State	Published - 1 Jun 2016

Keywords

Cardiovascular diseases
Drug delivery
Nanoparticles
Nanostructured
Polymers
Theranostic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.progpolymsci.2016.01.002

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title = "The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs",

abstract = "This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the possibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy.",

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author = "Wang, {Yen Jen} and Mikael Larsson and Huang, {Wei Ting} and Chiou, {Shih Hwa} and Nicholls, {Stephen J.} and Jui-I Chao and Dean-Mo LIu",

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T2 - Recent advances and emerging designs

AU - Wang, Yen Jen

AU - Larsson, Mikael

AU - Huang, Wei Ting

AU - Chiou, Shih Hwa

AU - Nicholls, Stephen J.

AU - Chao, Jui-I

AU - LIu, Dean-Mo

PY - 2016/6/1

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N2 - This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the possibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy.

AB - This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the possibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy.

KW - Cardiovascular diseases

KW - Drug delivery

KW - Nanoparticles

KW - Nanostructured

KW - Polymers

KW - Theranostic

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JO - Progress in Polymer Science

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The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs

Abstract

Keywords

UN SDGs

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