The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists

Shan Yen Chou; Su San Chen; Chin Chung Ho; Shiang Ling Huang; Tsai Mien Huang; Ohm Guo Pan; Chia Lin Wang; Ying Chen; Hsiao Hwa Lu; Shih Hwa Liu; Shir Ly Huang; Ren Shou Chiang

doi:10.1002/jccs.199600014

The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists

Shan Yen Chou^*, Su San Chen, Chin Chung Ho, Shiang Ling Huang, Tsai Mien Huang, Ohm Guo Pan, Chia Lin Wang, Ying Chen, Hsiao Hwa Lu, Shih Hwa Liu, Shir Ly Huang, Ren Shou Chiang

^*Corresponding author for this work

Institute of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The syntheses of triazole, sulfur-containing diazole and N-phenylthiatriazole analogs of imidazole angiotensin II antagonist, DuP 753, are reported. 5-Butyl-3-[(2-trifluoromethyl)phenyl]-2,1,3,4-1H-thiatriazole-2-one biphenyltetrazole (63) is found to have good in vitro activity.

Original language	English
Pages (from-to)	83-93
Number of pages	11
Journal	Journal of the Chinese Chemical Society
Volume	43
Issue number	1
DOIs	https://doi.org/10.1002/jccs.199600014
State	Published - 1996

Keywords

Angiotensin II antagonists
Oxathiadiazoles
Thiatriazoles

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10.1002/jccs.199600014

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Chou, S. Y., Chen, S. S., Ho, C. C., Huang, S. L., Huang, T. M., Pan, O. G., Wang, C. L., Chen, Y., Lu, H. H., Liu, S. H., Huang, S. L., & Chiang, R. S. (1996). The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists. Journal of the Chinese Chemical Society, 43(1), 83-93. https://doi.org/10.1002/jccs.199600014

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title = "The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists",

abstract = "The syntheses of triazole, sulfur-containing diazole and N-phenylthiatriazole analogs of imidazole angiotensin II antagonist, DuP 753, are reported. 5-Butyl-3-[(2-trifluoromethyl)phenyl]-2,1,3,4-1H-thiatriazole-2-one biphenyltetrazole (63) is found to have good in vitro activity.",

keywords = "Angiotensin II antagonists, Oxathiadiazoles, Thiatriazoles",

author = "Chou, {Shan Yen} and Chen, {Su San} and Ho, {Chin Chung} and Huang, {Shiang Ling} and Huang, {Tsai Mien} and Pan, {Ohm Guo} and Wang, {Chia Lin} and Ying Chen and Lu, {Hsiao Hwa} and Liu, {Shih Hwa} and Huang, {Shir Ly} and Chiang, {Ren Shou}",

year = "1996",

doi = "10.1002/jccs.199600014",

language = "English",

volume = "43",

pages = "83--93",

journal = "Journal of the Chinese Chemical Society",

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Chou, SY, Chen, SS, Ho, CC, Huang, SL, Huang, TM, Pan, OG, Wang, CL, Chen, Y, Lu, HH, Liu, SH, Huang, SL & Chiang, RS 1996, 'The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists', Journal of the Chinese Chemical Society, vol. 43, no. 1, pp. 83-93. https://doi.org/10.1002/jccs.199600014

TY - JOUR

T1 - The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists

AU - Chou, Shan Yen

AU - Chen, Su San

AU - Ho, Chin Chung

AU - Huang, Shiang Ling

AU - Huang, Tsai Mien

AU - Pan, Ohm Guo

AU - Wang, Chia Lin

AU - Chen, Ying

AU - Lu, Hsiao Hwa

AU - Liu, Shih Hwa

AU - Huang, Shir Ly

AU - Chiang, Ren Shou

PY - 1996

Y1 - 1996

N2 - The syntheses of triazole, sulfur-containing diazole and N-phenylthiatriazole analogs of imidazole angiotensin II antagonist, DuP 753, are reported. 5-Butyl-3-[(2-trifluoromethyl)phenyl]-2,1,3,4-1H-thiatriazole-2-one biphenyltetrazole (63) is found to have good in vitro activity.

AB - The syntheses of triazole, sulfur-containing diazole and N-phenylthiatriazole analogs of imidazole angiotensin II antagonist, DuP 753, are reported. 5-Butyl-3-[(2-trifluoromethyl)phenyl]-2,1,3,4-1H-thiatriazole-2-one biphenyltetrazole (63) is found to have good in vitro activity.

KW - Angiotensin II antagonists

KW - Oxathiadiazoles

KW - Thiatriazoles

UR - http://www.scopus.com/inward/record.url?scp=1542576020&partnerID=8YFLogxK

U2 - 10.1002/jccs.199600014

DO - 10.1002/jccs.199600014

M3 - Article

AN - SCOPUS:1542576020

SN - 0009-4536

VL - 43

SP - 83

EP - 93

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 1

ER -

The Syntheses of Triazole, Sulfur-Containing Diazole and N-Phenylthiatriazole Biphenyltetrazoles as Potential Angiotensin II Receptor Antagonists

Abstract

Keywords

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