The roles of alcohol dehydrogenase in patients with atrial fibrillation

Yu Feng Hu; Yao Ting Chang; Yenn Jiang Lin; Shih Lin Chang; Li Wei Lo; Yen Hua Huang; Tze Tze Liu; Che Hong Chen; Ta Chuan Tuan; Tze Fan Chao; Fa Po Chung; Jo Nan Liao; Abigail Louise D. Te; Chi Ying F. Huang; Shih Ann Chen

doi:10.1111/pace.13208

The roles of alcohol dehydrogenase in patients with atrial fibrillation

Yu Feng Hu^*, Yao Ting Chang, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Yen Hua Huang, Tze Tze Liu, Che Hong Chen, Ta Chuan Tuan, Tze Fan Chao, Fa Po Chung, Jo Nan Liao, Abigail Louise D. Te, Chi Ying F. Huang, Shih Ann Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Alcohol consumption is known to increase the risk of atrial fibrillation (AF). Whether the genotypes of alcohol-metabolizing genes (alcohol dehydrogenase [ADH1B]) are associated with the risk of AF recurrence after catheter ablation remains unclear. Methods and results: The ADH1B genotypes of 281 patients who received catheter ablation for AF were examined. We followed this group of patients to monitor their AF recurrence. Alcohol consumption levels of this cohort were evaluated before and after catheter ablation. There was no difference in the underlying diseases presented by the patients with different ADH1B genotypes. Regardless of the ADH1B genotypes, the amount of alcohol consumption was the only factor associated with left atrial dilatation. The ADH1B*2 alleles (hazard ratio: ADH1B*1/*2 vs *1/*1: 2.64; ADH1B*2/*2 vs *1/*1: 1.80, P = 0.02) and the levels of alcohol consumption were independently associated with AF recurrence in the patients with paroxysmal AF after catheter ablation. ADH1B polymorphisms were not associated with AF recurrence in the patients with nonparoxysmal AF. We also found that the association of increased AF recurrence with alcohol consumption and the ADH1B genotypes cannot be explained by mechanisms of systemic inflammation. Conclusions: ADH1B*2/*2 genotype and amount of alcohol consumption increase the risk of AF recurrence after catheter ablation.

Original language	English
Pages (from-to)	1446-1453
Number of pages	8
Journal	PACE - Pacing and Clinical Electrophysiology
Volume	40
Issue number	12
DOIs	https://doi.org/10.1111/pace.13208
State	Published - Dec 2017

Keywords

ADH1B
atrial fibrillation
catheter ablation

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10.1111/pace.13208

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Hu, Y. F., Chang, Y. T., Lin, Y. J., Chang, S. L., Lo, L. W., Huang, Y. H., Liu, T. T., Chen, C. H., Tuan, T. C., Chao, T. F., Chung, F. P., Liao, J. N., Te, A. L. D., Huang, C. Y. F., & Chen, S. A. (2017). The roles of alcohol dehydrogenase in patients with atrial fibrillation. PACE - Pacing and Clinical Electrophysiology, 40(12), 1446-1453. https://doi.org/10.1111/pace.13208

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title = "The roles of alcohol dehydrogenase in patients with atrial fibrillation",

abstract = "Background: Alcohol consumption is known to increase the risk of atrial fibrillation (AF). Whether the genotypes of alcohol-metabolizing genes (alcohol dehydrogenase [ADH1B]) are associated with the risk of AF recurrence after catheter ablation remains unclear. Methods and results: The ADH1B genotypes of 281 patients who received catheter ablation for AF were examined. We followed this group of patients to monitor their AF recurrence. Alcohol consumption levels of this cohort were evaluated before and after catheter ablation. There was no difference in the underlying diseases presented by the patients with different ADH1B genotypes. Regardless of the ADH1B genotypes, the amount of alcohol consumption was the only factor associated with left atrial dilatation. The ADH1B*2 alleles (hazard ratio: ADH1B*1/*2 vs *1/*1: 2.64; ADH1B*2/*2 vs *1/*1: 1.80, P = 0.02) and the levels of alcohol consumption were independently associated with AF recurrence in the patients with paroxysmal AF after catheter ablation. ADH1B polymorphisms were not associated with AF recurrence in the patients with nonparoxysmal AF. We also found that the association of increased AF recurrence with alcohol consumption and the ADH1B genotypes cannot be explained by mechanisms of systemic inflammation. Conclusions: ADH1B*2/*2 genotype and amount of alcohol consumption increase the risk of AF recurrence after catheter ablation.",

keywords = "ADH1B, atrial fibrillation, catheter ablation",

author = "Hu, {Yu Feng} and Chang, {Yao Ting} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Lo, {Li Wei} and Huang, {Yen Hua} and Liu, {Tze Tze} and Chen, {Che Hong} and Tuan, {Ta Chuan} and Chao, {Tze Fan} and Chung, {Fa Po} and Liao, {Jo Nan} and Te, {Abigail Louise D.} and Huang, {Chi Ying F.} and Chen, {Shih Ann}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2017",

month = dec,

doi = "10.1111/pace.13208",

language = "English",

volume = "40",

pages = "1446--1453",

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T1 - The roles of alcohol dehydrogenase in patients with atrial fibrillation

AU - Hu, Yu Feng

AU - Chang, Yao Ting

AU - Lin, Yenn Jiang

AU - Chang, Shih Lin

AU - Lo, Li Wei

AU - Huang, Yen Hua

AU - Liu, Tze Tze

AU - Chen, Che Hong

AU - Tuan, Ta Chuan

AU - Chao, Tze Fan

AU - Chung, Fa Po

AU - Liao, Jo Nan

AU - Te, Abigail Louise D.

AU - Huang, Chi Ying F.

AU - Chen, Shih Ann

PY - 2017/12

Y1 - 2017/12

N2 - Background: Alcohol consumption is known to increase the risk of atrial fibrillation (AF). Whether the genotypes of alcohol-metabolizing genes (alcohol dehydrogenase [ADH1B]) are associated with the risk of AF recurrence after catheter ablation remains unclear. Methods and results: The ADH1B genotypes of 281 patients who received catheter ablation for AF were examined. We followed this group of patients to monitor their AF recurrence. Alcohol consumption levels of this cohort were evaluated before and after catheter ablation. There was no difference in the underlying diseases presented by the patients with different ADH1B genotypes. Regardless of the ADH1B genotypes, the amount of alcohol consumption was the only factor associated with left atrial dilatation. The ADH1B*2 alleles (hazard ratio: ADH1B*1/*2 vs *1/*1: 2.64; ADH1B*2/*2 vs *1/*1: 1.80, P = 0.02) and the levels of alcohol consumption were independently associated with AF recurrence in the patients with paroxysmal AF after catheter ablation. ADH1B polymorphisms were not associated with AF recurrence in the patients with nonparoxysmal AF. We also found that the association of increased AF recurrence with alcohol consumption and the ADH1B genotypes cannot be explained by mechanisms of systemic inflammation. Conclusions: ADH1B*2/*2 genotype and amount of alcohol consumption increase the risk of AF recurrence after catheter ablation.

AB - Background: Alcohol consumption is known to increase the risk of atrial fibrillation (AF). Whether the genotypes of alcohol-metabolizing genes (alcohol dehydrogenase [ADH1B]) are associated with the risk of AF recurrence after catheter ablation remains unclear. Methods and results: The ADH1B genotypes of 281 patients who received catheter ablation for AF were examined. We followed this group of patients to monitor their AF recurrence. Alcohol consumption levels of this cohort were evaluated before and after catheter ablation. There was no difference in the underlying diseases presented by the patients with different ADH1B genotypes. Regardless of the ADH1B genotypes, the amount of alcohol consumption was the only factor associated with left atrial dilatation. The ADH1B*2 alleles (hazard ratio: ADH1B*1/*2 vs *1/*1: 2.64; ADH1B*2/*2 vs *1/*1: 1.80, P = 0.02) and the levels of alcohol consumption were independently associated with AF recurrence in the patients with paroxysmal AF after catheter ablation. ADH1B polymorphisms were not associated with AF recurrence in the patients with nonparoxysmal AF. We also found that the association of increased AF recurrence with alcohol consumption and the ADH1B genotypes cannot be explained by mechanisms of systemic inflammation. Conclusions: ADH1B*2/*2 genotype and amount of alcohol consumption increase the risk of AF recurrence after catheter ablation.

KW - ADH1B

KW - atrial fibrillation

KW - catheter ablation

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EP - 1453

JO - PACE - Pacing and Clinical Electrophysiology

JF - PACE - Pacing and Clinical Electrophysiology

IS - 12

ER -

The roles of alcohol dehydrogenase in patients with atrial fibrillation

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