The role of smoothened in cancer

Kuo Shyang Jeng; I. Shyan Sheen; Chuen Miin Leu; Ping Hui Tseng; Chiung Fang Chang

doi:10.3390/ijms21186863

The role of smoothened in cancer

Kuo Shyang Jeng, I. Shyan Sheen, Chuen Miin Leu, Ping Hui Tseng^*, Chiung Fang Chang

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. SMO expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. A better understanding of the role of SMO in cancer could contribute to the development of novel therapeutic approaches.

Original language	English
Article number	6863
Pages (from-to)	1-20
Number of pages	20
Journal	International Journal Of Molecular Sciences
Volume	21
Issue number	18
DOIs	https://doi.org/10.3390/ijms21186863
State	Published - 2 Sep 2020

Keywords

Cancer stem cells
Hedgehog signaling pathway
Smoothened

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms21186863

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title = "The role of smoothened in cancer",

abstract = "Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. SMO expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. A better understanding of the role of SMO in cancer could contribute to the development of novel therapeutic approaches.",

keywords = "Cancer stem cells, Hedgehog signaling pathway, Smoothened",

author = "Jeng, {Kuo Shyang} and Sheen, {I. Shyan} and Leu, {Chuen Miin} and Tseng, {Ping Hui} and Chang, {Chiung Fang}",

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T1 - The role of smoothened in cancer

AU - Jeng, Kuo Shyang

AU - Sheen, I. Shyan

AU - Leu, Chuen Miin

AU - Tseng, Ping Hui

AU - Chang, Chiung Fang

PY - 2020/9/2

Y1 - 2020/9/2

N2 - Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. SMO expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. A better understanding of the role of SMO in cancer could contribute to the development of novel therapeutic approaches.

AB - Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. The role of SMO has been discussed in different types of cancer, including breast, liver, pancreatic and colon cancers. SMO expression correlates with tumor size, invasiveness, metastasis and recurrence. In addition, SMO inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. A better understanding of the role of SMO in cancer could contribute to the development of novel therapeutic approaches.

KW - Cancer stem cells

KW - Hedgehog signaling pathway

KW - Smoothened

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The role of smoothened in cancer

Abstract

Keywords

UN SDGs

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