The role of microRNAs in modulating sirtuin 1 expression

Kun Ling Tsai, Li Hsin Chen, Yu Chih Chen, Chung Lan Kao, Liang Kung Chen, Shih Hwa Chiou*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Sirtuin 1 (SIRT1) plays an important role in regulating cellular physiological processes, such as metabolism, cell degeneration, cell growth, and cell survival. The recent reports showed that microRNAs (miRNAs) have emerged as the important regulators for cell proliferation, development, cancer formation, stress responses, cell death, and other physiological conditions in the past decade. More recently, miRNAs have revealed their prominent role in regulating gene expression and have provided new aspects of applications in diagnosis, prognosis, and therapeutic strategies in many human diseases. In the present review, we introduce and discuss the functions of SIRT1 and miRNAs. We also emphasize specific aspects of miRNAs that could modulate SIRT1-related signaling transduction and downstream effects, such as apoptosis, aging, and angiogenesis.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalJournal of Clinical Gerontology and Geriatrics
Issue number3
StatePublished - Sep 2011


  • MicroRNA
  • p53
  • SIRT1
  • Sirtuin


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