The role of genetic variants in human longevity

Wen Hung Chung, Ro Lan Dao, Liang Kung Chen, Shuen Iu Hung*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Human longevity is a complex phenotype with a strong genetic predisposition. Increasing evidence has revealed the genetic antecedents of human longevity. This article aims to review the data of various case/control association studies that examine the difference in genetic polymorphisms between long-lived people and younger subjects across different human populations. There are more than 100 candidate genes potentially involved in human longevity; this article particularly focuses on genes of the insulin/IGF-1 pathway, FOXO3A, FOXO1A, lipoprotein metabolism (e.g., APOE and PON1), and cell-cycle regulators (e.g., TP53 and P21). Since the confirmed genetic components for human longevity are few to date, further precise assessment of the genetic contributions is required. Gaining a better understanding of the contribution of genetics to human longevity may assist in the design of improved treatment methods for age-related diseases, delay the aging process, and, ultimately, prolong the human lifespan.

Original languageEnglish
Pages (from-to)S67-S78
JournalAgeing Research Reviews
Issue numberSUPPL.
StatePublished - Nov 2010


  • Aging
  • Genetics
  • Human
  • Longevity
  • Polymorphisms


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