The role of chemokines and chemokine receptors in diabetic nephropathy

Ting Ting Chang, Jaw Wen Chen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently available, DN is still the major cause of end-stage renal disease. Accordingly, widespread innovation is needed to improve outcomes in patients with DN. Chemokines and their receptors are critically involved in the inflammatory progression in the development of DN. Although recent studies have shown multiple pathways related to the chemokine system, the specific and direct effects of chemokines and their receptors remain unclear. In this review, we provide an overview of the potential role and mechanism of chemokine systems in DN proposed in recent years. Chemokine system-related mechanisms may provide potential therapeutic targets in DN.

Original languageEnglish
Article number3172
JournalInternational Journal Of Molecular Sciences
Issue number9
StatePublished - 1 May 2020


  • Chemokine
  • Chemokine receptor
  • Diabetes mellitus
  • Diabetic nephropathy
  • Inflammation


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