The Number of Risk Factors Determines the Outcome Of Stage II Colorectal Cancer Patients

Hung Hsin Lin; Hsueh Li Yang; Jen Kou Lin; Chun Chi Lin; Huann Sheng Wang; Shung Haur Yang; Jeng Kai Jiang; Yuan Tzu Lan; Tzu Chen Lin; Wei Shone Chen; Wen Yih Liang; Shih Ching Chang

The Number of Risk Factors Determines the Outcome Of Stage II Colorectal Cancer Patients

Hung Hsin Lin, Hsueh Li Yang, Jen Kou Lin, Chun Chi Lin, Huann Sheng Wang, Shung Haur Yang, Jeng Kai Jiang, Yuan Tzu Lan, Tzu Chen Lin, Wei Shone Chen, Wen Yih Liang, Shih Ching Chang

Department of Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

BACKGROUND/AIMS: We evaluated the prognostic significance of clinicopathologic features recommended by the majority of guidelines for identifying high-risk stage it colon cancer patients.

METHODOLOGY: We enrolled 665 stage II colorectal cancer patients at Taipei Veterans General Hospital in 2002-2006. Patients who received preoperative or postoperative chemotherapy were excluded (124). The measured endpoint was disease-free survival.

RESULTS: Of 541 patients, 59 showed stage T4 tumors; 35, lymphovascular invasion; 19, poor differentiation, and 251, carcinoembryonic antigen levels of > 5 ng/mL; 53 underwent emergent operations. Colorectal cancer recurred in 84 patients. The 5-year disease-free survival rate was 84.5%. Univariate and multivariate analyses revealed 3 independent factors affecting the prognosis significantly tumor stage T4, high carcinoembryonic antigen level, and presence of lymphovascular invasion. Considering the cumulative effect of risk factors, the 5-year disease-free survival rate of patients with tumors without any risk factor was 90.2%, which was significantly better than that of patients with 1 or 2 risk factors (82.3%, 61.6%).

CONCLUSIONS: Stage II colorectal cancer patients had excellent outcome. Ad juvant chemotherapy may be warranted for patients with multiple risk factors.

Original language	English
Pages (from-to)	1024-1027
Number of pages	4
Journal	Hepato-Gastroenterology
Volume	61
Issue number	132
State	Published - 1 Jun 2014

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title = "The Number of Risk Factors Determines the Outcome Of Stage II Colorectal Cancer Patients",

abstract = "BACKGROUND/AIMS: We evaluated the prognostic significance of clinicopathologic features recommended by the majority of guidelines for identifying high-risk stage it colon cancer patients.METHODOLOGY: We enrolled 665 stage II colorectal cancer patients at Taipei Veterans General Hospital in 2002-2006. Patients who received preoperative or postoperative chemotherapy were excluded (124). The measured endpoint was disease-free survival.RESULTS: Of 541 patients, 59 showed stage T4 tumors; 35, lymphovascular invasion; 19, poor differentiation, and 251, carcinoembryonic antigen levels of > 5 ng/mL; 53 underwent emergent operations. Colorectal cancer recurred in 84 patients. The 5-year disease-free survival rate was 84.5%. Univariate and multivariate analyses revealed 3 independent factors affecting the prognosis significantly tumor stage T4, high carcinoembryonic antigen level, and presence of lymphovascular invasion. Considering the cumulative effect of risk factors, the 5-year disease-free survival rate of patients with tumors without any risk factor was 90.2%, which was significantly better than that of patients with 1 or 2 risk factors (82.3%, 61.6%).CONCLUSIONS: Stage II colorectal cancer patients had excellent outcome. Ad juvant chemotherapy may be warranted for patients with multiple risk factors.",

author = "Lin, {Hung Hsin} and Yang, {Hsueh Li} and Lin, {Jen Kou} and Lin, {Chun Chi} and Wang, {Huann Sheng} and Yang, {Shung Haur} and Jiang, {Jeng Kai} and Lan, {Yuan Tzu} and Lin, {Tzu Chen} and Chen, {Wei Shone} and Liang, {Wen Yih} and Chang, {Shih Ching}",

year = "2014",

month = jun,

day = "1",

language = "English",

volume = "61",

pages = "1024--1027",

journal = "Hepato-Gastroenterology",

issn = "0172-6390",

publisher = "H.G.E. Update Medical Publishing Ltd.",

number = "132",

}

TY - JOUR

T1 - The Number of Risk Factors Determines the Outcome Of Stage II Colorectal Cancer Patients

AU - Lin, Hung Hsin

AU - Yang, Hsueh Li

AU - Lin, Jen Kou

AU - Lin, Chun Chi

AU - Wang, Huann Sheng

AU - Yang, Shung Haur

AU - Jiang, Jeng Kai

AU - Lan, Yuan Tzu

AU - Lin, Tzu Chen

AU - Chen, Wei Shone

AU - Liang, Wen Yih

AU - Chang, Shih Ching

PY - 2014/6/1

Y1 - 2014/6/1

N2 - BACKGROUND/AIMS: We evaluated the prognostic significance of clinicopathologic features recommended by the majority of guidelines for identifying high-risk stage it colon cancer patients.METHODOLOGY: We enrolled 665 stage II colorectal cancer patients at Taipei Veterans General Hospital in 2002-2006. Patients who received preoperative or postoperative chemotherapy were excluded (124). The measured endpoint was disease-free survival.RESULTS: Of 541 patients, 59 showed stage T4 tumors; 35, lymphovascular invasion; 19, poor differentiation, and 251, carcinoembryonic antigen levels of > 5 ng/mL; 53 underwent emergent operations. Colorectal cancer recurred in 84 patients. The 5-year disease-free survival rate was 84.5%. Univariate and multivariate analyses revealed 3 independent factors affecting the prognosis significantly tumor stage T4, high carcinoembryonic antigen level, and presence of lymphovascular invasion. Considering the cumulative effect of risk factors, the 5-year disease-free survival rate of patients with tumors without any risk factor was 90.2%, which was significantly better than that of patients with 1 or 2 risk factors (82.3%, 61.6%).CONCLUSIONS: Stage II colorectal cancer patients had excellent outcome. Ad juvant chemotherapy may be warranted for patients with multiple risk factors.

AB - BACKGROUND/AIMS: We evaluated the prognostic significance of clinicopathologic features recommended by the majority of guidelines for identifying high-risk stage it colon cancer patients.METHODOLOGY: We enrolled 665 stage II colorectal cancer patients at Taipei Veterans General Hospital in 2002-2006. Patients who received preoperative or postoperative chemotherapy were excluded (124). The measured endpoint was disease-free survival.RESULTS: Of 541 patients, 59 showed stage T4 tumors; 35, lymphovascular invasion; 19, poor differentiation, and 251, carcinoembryonic antigen levels of > 5 ng/mL; 53 underwent emergent operations. Colorectal cancer recurred in 84 patients. The 5-year disease-free survival rate was 84.5%. Univariate and multivariate analyses revealed 3 independent factors affecting the prognosis significantly tumor stage T4, high carcinoembryonic antigen level, and presence of lymphovascular invasion. Considering the cumulative effect of risk factors, the 5-year disease-free survival rate of patients with tumors without any risk factor was 90.2%, which was significantly better than that of patients with 1 or 2 risk factors (82.3%, 61.6%).CONCLUSIONS: Stage II colorectal cancer patients had excellent outcome. Ad juvant chemotherapy may be warranted for patients with multiple risk factors.

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M3 - Article

C2 - 26158160

AN - SCOPUS:84938927191

SN - 0172-6390

VL - 61

SP - 1024

EP - 1027

JO - Hepato-Gastroenterology

JF - Hepato-Gastroenterology

IS - 132

ER -

The Number of Risk Factors Determines the Outcome Of Stage II Colorectal Cancer Patients

Abstract

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