The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells

Aditi Falnikar; Sebastian Quintremil; Hung Jun Zhao; Haw Yuan Cheng; Paige Helmer; Jin Wu Tsai; Richard B. Vallee

doi:10.1016/j.celrep.2024.115008

The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells

Aditi Falnikar^*, Sebastian Quintremil, Hung Jun Zhao, Haw Yuan Cheng, Paige Helmer, Jin Wu Tsai, Richard B. Vallee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Radial glial progenitors (RGPs) are highly elongated epithelial cells that give rise to most stem cells, neurons, and glia in the vertebrate cerebral cortex. During development, the RGP nuclei exhibit a striking pattern of cell-cycle-dependent oscillatory movements known as interkinetic nuclear migration (INM), which we previously found to be mediated during G1 by the kinesin Kif1a and during G2 by cytoplasmic dynein, recruited to the nuclear envelope by the nucleoporins RanBP2 and Nup133. We now identify Nup153 as a nucleoporin anchor for Kif1a, responsible for G1-specific basal nuclear migration, providing a complete model for the mechanisms underlying this basic but mysterious behavior, with broad implications for understanding brain development.

Original language	English
Article number	115008
Journal	Cell Reports
Volume	43
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2024.115008
State	Published - 24 Dec 2024

Keywords

CP: Cell biology
CP: Neuroscience
Kif1a
Nup153
brain development
cell cycle regulation
interkinetic nuclear migration
neuronal migration

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10.1016/j.celrep.2024.115008

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title = "The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells",

abstract = "Radial glial progenitors (RGPs) are highly elongated epithelial cells that give rise to most stem cells, neurons, and glia in the vertebrate cerebral cortex. During development, the RGP nuclei exhibit a striking pattern of cell-cycle-dependent oscillatory movements known as interkinetic nuclear migration (INM), which we previously found to be mediated during G1 by the kinesin Kif1a and during G2 by cytoplasmic dynein, recruited to the nuclear envelope by the nucleoporins RanBP2 and Nup133. We now identify Nup153 as a nucleoporin anchor for Kif1a, responsible for G1-specific basal nuclear migration, providing a complete model for the mechanisms underlying this basic but mysterious behavior, with broad implications for understanding brain development.",

keywords = "CP: Cell biology, CP: Neuroscience, Kif1a, Nup153, brain development, cell cycle regulation, interkinetic nuclear migration, neuronal migration",

author = "Aditi Falnikar and Sebastian Quintremil and Zhao, {Hung Jun} and Cheng, {Haw Yuan} and Paige Helmer and Tsai, {Jin Wu} and Vallee, {Richard B.}",

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doi = "10.1016/j.celrep.2024.115008",

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T1 - The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells

AU - Falnikar, Aditi

AU - Quintremil, Sebastian

AU - Zhao, Hung Jun

AU - Cheng, Haw Yuan

AU - Helmer, Paige

AU - Tsai, Jin Wu

AU - Vallee, Richard B.

PY - 2024/12/24

Y1 - 2024/12/24

N2 - Radial glial progenitors (RGPs) are highly elongated epithelial cells that give rise to most stem cells, neurons, and glia in the vertebrate cerebral cortex. During development, the RGP nuclei exhibit a striking pattern of cell-cycle-dependent oscillatory movements known as interkinetic nuclear migration (INM), which we previously found to be mediated during G1 by the kinesin Kif1a and during G2 by cytoplasmic dynein, recruited to the nuclear envelope by the nucleoporins RanBP2 and Nup133. We now identify Nup153 as a nucleoporin anchor for Kif1a, responsible for G1-specific basal nuclear migration, providing a complete model for the mechanisms underlying this basic but mysterious behavior, with broad implications for understanding brain development.

AB - Radial glial progenitors (RGPs) are highly elongated epithelial cells that give rise to most stem cells, neurons, and glia in the vertebrate cerebral cortex. During development, the RGP nuclei exhibit a striking pattern of cell-cycle-dependent oscillatory movements known as interkinetic nuclear migration (INM), which we previously found to be mediated during G1 by the kinesin Kif1a and during G2 by cytoplasmic dynein, recruited to the nuclear envelope by the nucleoporins RanBP2 and Nup133. We now identify Nup153 as a nucleoporin anchor for Kif1a, responsible for G1-specific basal nuclear migration, providing a complete model for the mechanisms underlying this basic but mysterious behavior, with broad implications for understanding brain development.

KW - CP: Cell biology

KW - CP: Neuroscience

KW - Kif1a

KW - Nup153

KW - brain development

KW - cell cycle regulation

KW - interkinetic nuclear migration

KW - neuronal migration

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DO - 10.1016/j.celrep.2024.115008

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JO - Cell Reports

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ER -

The nucleoporin Nup153 is the anchor for Kif1a during basal nuclear migration in brain progenitor cells

Abstract

Keywords

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