The Lysosome in Malignant Melanoma: Biology, Function and Therapeutic Applications

Chia Hsin Hsu; Keng Jung Lee; Yi Han Chiu; Kuo Ching Huang; Guo Shou Wang; Lei Po Chen; Kuang Wen Liao; Chen Si Lin

doi:10.3390/cells11091492

The Lysosome in Malignant Melanoma: Biology, Function and Therapeutic Applications

Chia Hsin Hsu, Keng Jung Lee, Yi Han Chiu, Kuo Ching Huang, Guo Shou Wang, Lei Po Chen, Kuang Wen Liao, Chen Si Lin^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Lysosomes are membrane-bound vesicles that play roles in the degradation and recycling of cellular waste and homeostasis maintenance within cells. False alterations of lysosomal functions can lead to broad detrimental effects and cause various diseases, including cancers. Cancer cells that are rapidly proliferative and invasive are highly dependent on effective lysosomal function. Malignant melanoma is the most lethal form of skin cancer, with high metastasis characteristics, drug resistance, and aggressiveness. It is critical to understand the role of lysosomes in melanoma pathogenesis in order to improve the outcomes of melanoma patients. In this mini-review, we compile our current knowledge of lysosomes’ role in tumorigenesis, progression, therapy resistance, and the current treatment strategies related to lysosomes in melanoma.

Original language	English
Article number	1492
Journal	Cells
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/cells11091492
State	Published - 1 May 2022

Keywords

chemoresistance
lysosome biogenesis
melanoma therapy target

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells11091492

Cite this

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title = "The Lysosome in Malignant Melanoma: Biology, Function and Therapeutic Applications",

abstract = "Lysosomes are membrane-bound vesicles that play roles in the degradation and recycling of cellular waste and homeostasis maintenance within cells. False alterations of lysosomal functions can lead to broad detrimental effects and cause various diseases, including cancers. Cancer cells that are rapidly proliferative and invasive are highly dependent on effective lysosomal function. Malignant melanoma is the most lethal form of skin cancer, with high metastasis characteristics, drug resistance, and aggressiveness. It is critical to understand the role of lysosomes in melanoma pathogenesis in order to improve the outcomes of melanoma patients. In this mini-review, we compile our current knowledge of lysosomes{\textquoteright} role in tumorigenesis, progression, therapy resistance, and the current treatment strategies related to lysosomes in melanoma.",

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doi = "10.3390/cells11091492",

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T1 - The Lysosome in Malignant Melanoma

T2 - Biology, Function and Therapeutic Applications

AU - Hsu, Chia Hsin

AU - Lee, Keng Jung

AU - Chiu, Yi Han

AU - Huang, Kuo Ching

AU - Wang, Guo Shou

AU - Chen, Lei Po

AU - Liao, Kuang Wen

AU - Lin, Chen Si

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Lysosomes are membrane-bound vesicles that play roles in the degradation and recycling of cellular waste and homeostasis maintenance within cells. False alterations of lysosomal functions can lead to broad detrimental effects and cause various diseases, including cancers. Cancer cells that are rapidly proliferative and invasive are highly dependent on effective lysosomal function. Malignant melanoma is the most lethal form of skin cancer, with high metastasis characteristics, drug resistance, and aggressiveness. It is critical to understand the role of lysosomes in melanoma pathogenesis in order to improve the outcomes of melanoma patients. In this mini-review, we compile our current knowledge of lysosomes’ role in tumorigenesis, progression, therapy resistance, and the current treatment strategies related to lysosomes in melanoma.

AB - Lysosomes are membrane-bound vesicles that play roles in the degradation and recycling of cellular waste and homeostasis maintenance within cells. False alterations of lysosomal functions can lead to broad detrimental effects and cause various diseases, including cancers. Cancer cells that are rapidly proliferative and invasive are highly dependent on effective lysosomal function. Malignant melanoma is the most lethal form of skin cancer, with high metastasis characteristics, drug resistance, and aggressiveness. It is critical to understand the role of lysosomes in melanoma pathogenesis in order to improve the outcomes of melanoma patients. In this mini-review, we compile our current knowledge of lysosomes’ role in tumorigenesis, progression, therapy resistance, and the current treatment strategies related to lysosomes in melanoma.

KW - chemoresistance

KW - lysosome biogenesis

KW - melanoma therapy target

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U2 - 10.3390/cells11091492

DO - 10.3390/cells11091492

M3 - Review article

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SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

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ER -

The Lysosome in Malignant Melanoma: Biology, Function and Therapeutic Applications

Abstract

Keywords

UN SDGs

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