The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures

Chieh Chen; Cheng Yu Tsai; Yu Ting Cheng; Hsiao En Tsai; Yung Chieh Lo

doi:10.1109/MEMS58180.2024.10439402

The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures

Chieh Chen
, Cheng Yu Tsai
, Yu Ting Cheng^*
, Hsiao En Tsai
, Yung Chieh Lo

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

In this paper, we develop and investigate three molecularly imprinted polymer (MIP)-based sensing electrode, each with a unique nanostructured composite design, for direct detection of ultra-low concentration cardiac troponin T (cTnT) in urine. Experimental results show that the electrode with pinhole, mushroom, and coral-shaped nanostructures can achieve a limit of detection (LoD) of 13.02, 7.835, and 4.462 pg/ml, respectively. Surface roughness and porosity emerge as pivotal factors influencing electrode performance. Increasing the sensing surface area significantly improved the sensor's performance. The coral structure's practicality for clinical applications, aligned with healthy adult urine concentrations, makes it promising for predicting cardiovascular diseases.

Original language	English
Title of host publication	IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	312-315
Number of pages	4
ISBN (Electronic)	9798350357929
DOIs	https://doi.org/10.1109/MEMS58180.2024.10439402
State	Published - 2024
Event	37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024 - Austin, United States Duration: 21 Jan 2024 → 25 Jan 2024

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024
Country/Territory	United States
City	Austin
Period	21/01/24 → 25/01/24

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Troponin T
anodic aluminum oxide
methylene-blue
molecularly imprinted polymer
nanocomposite structure
urine testing

Access to Document

10.1109/MEMS58180.2024.10439402

Cite this

Chen, C., Tsai, C. Y., Cheng, Y. T., Tsai, H. E., & Lo, Y. C. (2024). The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures. In IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024 (pp. 312-315). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS58180.2024.10439402

Chen, Chieh ; Tsai, Cheng Yu ; Cheng, Yu Ting et al. / The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures. IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024. Institute of Electrical and Electronics Engineers Inc., 2024. pp. 312-315 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

@inproceedings{3268c1d8b8f9407887c6b3fcfdbc826c,

title = "The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures",

abstract = "In this paper, we develop and investigate three molecularly imprinted polymer (MIP)-based sensing electrode, each with a unique nanostructured composite design, for direct detection of ultra-low concentration cardiac troponin T (cTnT) in urine. Experimental results show that the electrode with pinhole, mushroom, and coral-shaped nanostructures can achieve a limit of detection (LoD) of 13.02, 7.835, and 4.462 pg/ml, respectively. Surface roughness and porosity emerge as pivotal factors influencing electrode performance. Increasing the sensing surface area significantly improved the sensor's performance. The coral structure's practicality for clinical applications, aligned with healthy adult urine concentrations, makes it promising for predicting cardiovascular diseases.",

keywords = "Troponin T, anodic aluminum oxide, methylene-blue, molecularly imprinted polymer, nanocomposite structure, urine testing",

author = "Chieh Chen and Tsai, \{Cheng Yu\} and Cheng, \{Yu Ting\} and Tsai, \{Hsiao En\} and Lo, \{Yung Chieh\}",

note = "Publisher Copyright: {\textcopyright} 2024 IEEE.; 37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024 ; Conference date: 21-01-2024 Through 25-01-2024",

year = "2024",

doi = "10.1109/MEMS58180.2024.10439402",

language = "English",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "312--315",

booktitle = "IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024",

address = "美國",

}

Chen, C, Tsai, CY, Cheng, YT, Tsai, HE & Lo, YC 2024, The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures. in IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers Inc., pp. 312-315, 37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024, Austin, United States, 21/01/24. https://doi.org/10.1109/MEMS58180.2024.10439402

The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures. / Chen, Chieh; Tsai, Cheng Yu; Cheng, Yu Ting et al.
IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024. Institute of Electrical and Electronics Engineers Inc., 2024. p. 312-315 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures

AU - Chen, Chieh

AU - Tsai, Cheng Yu

AU - Cheng, Yu Ting

AU - Tsai, Hsiao En

AU - Lo, Yung Chieh

PY - 2024

Y1 - 2024

N2 - In this paper, we develop and investigate three molecularly imprinted polymer (MIP)-based sensing electrode, each with a unique nanostructured composite design, for direct detection of ultra-low concentration cardiac troponin T (cTnT) in urine. Experimental results show that the electrode with pinhole, mushroom, and coral-shaped nanostructures can achieve a limit of detection (LoD) of 13.02, 7.835, and 4.462 pg/ml, respectively. Surface roughness and porosity emerge as pivotal factors influencing electrode performance. Increasing the sensing surface area significantly improved the sensor's performance. The coral structure's practicality for clinical applications, aligned with healthy adult urine concentrations, makes it promising for predicting cardiovascular diseases.

AB - In this paper, we develop and investigate three molecularly imprinted polymer (MIP)-based sensing electrode, each with a unique nanostructured composite design, for direct detection of ultra-low concentration cardiac troponin T (cTnT) in urine. Experimental results show that the electrode with pinhole, mushroom, and coral-shaped nanostructures can achieve a limit of detection (LoD) of 13.02, 7.835, and 4.462 pg/ml, respectively. Surface roughness and porosity emerge as pivotal factors influencing electrode performance. Increasing the sensing surface area significantly improved the sensor's performance. The coral structure's practicality for clinical applications, aligned with healthy adult urine concentrations, makes it promising for predicting cardiovascular diseases.

KW - Troponin T

KW - anodic aluminum oxide

KW - methylene-blue

KW - molecularly imprinted polymer

KW - nanocomposite structure

KW - urine testing

UR - https://www.scopus.com/pages/publications/85186730738

U2 - 10.1109/MEMS58180.2024.10439402

DO - 10.1109/MEMS58180.2024.10439402

M3 - Conference contribution

AN - SCOPUS:85186730738

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

SP - 312

EP - 315

BT - IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024

Y2 - 21 January 2024 through 25 January 2024

ER -

Chen C, Tsai CY, Cheng YT, Tsai HE, Lo YC. The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures. In IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024. Institute of Electrical and Electronics Engineers Inc. 2024. p. 312-315. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS58180.2024.10439402

The LoD Enhancement Study of MIP-Based Troponin T in Urine Sensing Electrodes Using Modified Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Structures

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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