The impact of the synergistic effect of temperature and air pollutants on chronic lung diseases in subtropical Taiwan

Da Wei Wu, Szu Chia Chen, Hung Pin Tu, Chih Wen Wang, Chih Hsing Hung, Huang Chi Chen, Tzu Yu Kuo, Chen Feng Wang, Bo Cheng Lai, Pei Shih Chen*, Chao Hung Kuo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Previous studies have suggested an association between air pollution and lung disease. However, few studies have explored the relationship between chronic lung diseases classified by lung function and environmental parameters. This study aimed to comprehensively investigate the relationship between chronic lung diseases, air pollution, meteorological factors, and anthropomet-ric indices. We conducted a cross-sectional study using the Taiwan Biobank and the Taiwan Air Quality Monitoring Database. A total of 2889 participants were included. We found a V/U-shaped relationship between temperature and air pollutants, with significant effects at both high and low temperatures. In addition, at lower temperatures (<24.6 °C), air pollutants including carbon monoxide (CO) (adjusted OR (aOR):1.78/Log 1 ppb, 95% CI 0.98–3.25; aOR:5.35/Log 1 ppb, 95% CI 2.88– 9.94), nitrogen monoxide (NO) (aOR:1.05/ppm, 95% CI 1.01–1.09; aOR:1.11/ppm, 95% CI 1.07–1.15), nitrogen oxides (NOx) (aOR:1.02/ppm, 95% CI 1.00–1.05; aOR:1.06/ppm, 95% CI 1.04–1.08), and sulfur dioxide (SO2) (aOR:1.29/ppm, 95% CI 1.01–1.65; aOR:1.77/ppm, 95% CI 1.36–2.30) were associated with restrictive and mixed lung diseases, respectively. Exposure to CO, NO, NO2, NOx and SO2 significantly affected obstructive and mixed lung disease in southern Taiwan. In conclusion, temperature and air pollution should be considered together when evaluating the impact on chronic lung diseases.

Original languageEnglish
Article number819
JournalJournal of Personalized Medicine
Issue number8
StatePublished - Aug 2021


  • Air pollution
  • Chronic lung disease
  • Temperature


Dive into the research topics of 'The impact of the synergistic effect of temperature and air pollutants on chronic lung diseases in subtropical Taiwan'. Together they form a unique fingerprint.

Cite this