The impact of influenza vaccination on hospitalizations and mortality among frail older people

Wei Ju Lee, Liang Kung Chen, Gau Jun Tang, Tzuo Yun Lan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objectives: The objective of this study was to evaluate the benefits of influenza vaccination against hospitalization and mortality on frail elderly people. Design: The design was a population-based retrospective cohort study. Setting: Taiwan's National Health Insurance claims data. Participants: Participants were 5063 frail seniors, followed up for four years. Measurements: Measurements included age, gender, socioeconomic status, living areas, use of annual health examinations, comorbid conditions, use of influenza vaccine, frailty as defined by the Adjusted Clinical Group, hospitalization, and mortality in the observation period. The efficacy was presented as comparing ever versus never vaccinated people during the entire study period without regard to seasons. Results: Compared with those without influenza vaccination, vaccinated elderly individuals were younger, more likely to be men, have higher socioeconomic status, live in rural areas, have a higher rate of receiving a health examination, and have similar medical conditions. In the Cox proportional hazards analysis, influenza vaccination reduced by 7% the risk of hospitalization (95% confidence interval [CI] 0.86-0.99) and by 44% the risk of mortality (95% CI 0.51-0.62). Conclusion: Influenza vaccination was effective against hospitalization and mortality among the frail elderly. These results uphold the current universal influenza vaccination policy, and encourage policymakers to adopt strategies to improve vaccination use.

Original languageEnglish
Pages (from-to)256-260
Number of pages5
JournalJournal of the American Medical Directors Association
Issue number4
StatePublished - Apr 2014


  • Death
  • Hospitalization
  • Influenza vaccination
  • Older adults


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