TY - JOUR
T1 - The Extracellular Fluid-to-Intracellular Fluid Volume Ratio Is Associated with Large-Artery Structure and Function in Hemodialysis Patients
AU - Lin, Yao Ping
AU - Yu, Wen Chung
AU - Hsu, Tsei Lieh
AU - Ding, Philip Yu An
AU - Yang, Wu Chang
AU - Chen, Chen Huan
N1 - Funding Information:
Supported in part by grants no. NSC 88-2314-B-075-074 and NSC 89-2314-B-010-016 from the National Science Council; and intramural grants no. VGH 87-306, VGH 88-304, VGH 89-257, and VGH 90-66 from the Taipei Veterans General Hospital, Taiwan, ROC.
PY - 2003/11
Y1 - 2003/11
N2 - Background: Large-artery derangement is a major risk factor for cardiovascular and all-cause mortality in patients with end-stage renal disease (ESRD). It is not clear how body fluid distribution affects large-artery structure and function in patients with ESRD. Methods: One hundred fifty-seven hemodialysis (HD) patients (mean age, 55.9 ± 15.1 years; 76 men, 81 women) were enrolled. Influence of the extracellular fluid (ECF)-to-intracellular fluid (ICF) ratio derived from bioimpedance spectroscopy on the structure and function of the common carotid artery (CCA) and aorta was analyzed. One hundred forty-four healthy subjects were examined to obtain normal reference values for body fluid compartments. Based on ECF-ICF ratio, 2 groups were identified: ECF-ICF ratio in the 95th percentile or less and ECF-ICF ratio greater than the 95th percentile of age- and sex-stratified normal reference values. Results: ECF-ICF ratio was significantly related to CCA diameter (r2 = 0.26; P < 0.001), CCA incremental modulus (Einc; r2 = 0.15; P < 0.001), carotid augmentation index (AGI; r2 = 0.10; P < 0.001), and aortic pulse wave velocity (aPWV; r2 = 0.21; P < 0.001). ECF-ICF ratio remained a significant independent determinant for CCA diameter (model r2 = 0.47; P < 0.001), Einc (12 = 0.29; P < 0.001), aPWV (r 2 = 0.51; P < 0.001), and AGI (r2 = 0.40; P < 0.001) when age, sex, mean blood pressure, anthropometrical parameters, HD duration, and status of diabetes mellitus were accounted for. HD patients with an ECF-ICF ratio greater than the 95th percentile had a greater CCA diameter, Einc, aPWV, and AGI than their counterparts. Conclusion: ECF-ICF ratio is associated with large-artery structure and function in HD patients. Patients with ESRD with a high ECF-ICF ratio are characterized by significant large-artery derangement.
AB - Background: Large-artery derangement is a major risk factor for cardiovascular and all-cause mortality in patients with end-stage renal disease (ESRD). It is not clear how body fluid distribution affects large-artery structure and function in patients with ESRD. Methods: One hundred fifty-seven hemodialysis (HD) patients (mean age, 55.9 ± 15.1 years; 76 men, 81 women) were enrolled. Influence of the extracellular fluid (ECF)-to-intracellular fluid (ICF) ratio derived from bioimpedance spectroscopy on the structure and function of the common carotid artery (CCA) and aorta was analyzed. One hundred forty-four healthy subjects were examined to obtain normal reference values for body fluid compartments. Based on ECF-ICF ratio, 2 groups were identified: ECF-ICF ratio in the 95th percentile or less and ECF-ICF ratio greater than the 95th percentile of age- and sex-stratified normal reference values. Results: ECF-ICF ratio was significantly related to CCA diameter (r2 = 0.26; P < 0.001), CCA incremental modulus (Einc; r2 = 0.15; P < 0.001), carotid augmentation index (AGI; r2 = 0.10; P < 0.001), and aortic pulse wave velocity (aPWV; r2 = 0.21; P < 0.001). ECF-ICF ratio remained a significant independent determinant for CCA diameter (model r2 = 0.47; P < 0.001), Einc (12 = 0.29; P < 0.001), aPWV (r 2 = 0.51; P < 0.001), and AGI (r2 = 0.40; P < 0.001) when age, sex, mean blood pressure, anthropometrical parameters, HD duration, and status of diabetes mellitus were accounted for. HD patients with an ECF-ICF ratio greater than the 95th percentile had a greater CCA diameter, Einc, aPWV, and AGI than their counterparts. Conclusion: ECF-ICF ratio is associated with large-artery structure and function in HD patients. Patients with ESRD with a high ECF-ICF ratio are characterized by significant large-artery derangement.
KW - Arteriosclerosis
KW - Bioimpedance
KW - Extracellular fluid volume (ECF)
KW - Hemodialysis (HD)
UR - http://www.scopus.com/inward/record.url?scp=0142219916&partnerID=8YFLogxK
U2 - 10.1016/j.ajkd.2003.07.002
DO - 10.1016/j.ajkd.2003.07.002
M3 - Article
C2 - 14582043
AN - SCOPUS:0142219916
SN - 0272-6386
VL - 42
SP - 990
EP - 999
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 5
ER -