The effect of far-infrared therapy on the peritoneal expression of glucose degradation products in diabetic patients on peritoneal dialysis

Chia Ning Chang, Chih Yuan Niu, Ann Charis Tan, Chia Hao Chan, Chun Fan Chen, Tz Heng Chen, Szu Yuan Li, Yung Tai Chen, Fan Yu Chen, Wen Sheng Liu, Chih Ching Lin*, Guor Jien Wei

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Peritoneal dialysis (PD) is a treatment modality for end-stage renal disease (ESRD) pa-tients. Dextrose is a common osmotic agent used in PD solutions and its absorption may exacerbate diabetes mellitus, a common complication of ESRD. PD solutions also contain glucose degradation products (GDPs) that may lead to encapsulating peritoneal sclerosis (EPS), a severe complication of PD. A previous study showed that far-infrared (FIR) therapy improved a patient’s gastrointestinal symptoms due to EPS. Due to limited literature on the matter, this study aims to investigate dialy-sate GDPs and peritoneal function in diabetic patients on PD. Thirty-one PD patients were enrolled and underwent 40 min of FIR therapy twice daily for six months. We demonstrated the effect of FIR therapy on the following: (1) decrease of methylglyoxal (p = 0.02), furfural (p = 0.005), and 5-hy-droxymethylfurfural (p = 0.03), (2) increase of D/D0 glucose ratio (p = 0.03), and (3) decrease of po-tassium levels (p = 0.008) in both DM and non-DM patients, as well as (4) maintenance and increase of peritoneal Kt/V in DM and non-DM patients, respectively (p = 0.03). FIR therapy is a non-invasive intervention that can decrease dialysate GDPs in PD patients by improving peritoneal transport rate and solute removal clearance, while also maintaining dialysis adequacy.

Original languageEnglish
Article number3732
JournalInternational Journal Of Molecular Sciences
Volume22
Issue number7
DOIs
StatePublished - 1 Apr 2021

Keywords

  • Diabetes mellitus
  • Far-infrared therapy
  • Glucose degradation products
  • Peritoneal dialysis

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