The clinicopathological characteristics and genetic alterations between younger and older gastric cancer patients with curative surgery

Chew Wun Wu, Ming Huang Chen, Kuo Hung Huang, Shih Ching Chang, Wen Liang Fang*, Chien Hsing Lin, Yee Chao, Su Shun Lo, Anna Fen Yau Li, Yi Ming Shyr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Few reports have investigated different genetic alterations according to age in various cancers. In total, 1749 GC patients receiving curative surgery were enrolled. The clinicopathological features, and prognoses were compared between younger (<65 years) and older (≥65 years) patients. Genetic mutations were analyzed using mass spectrometric single nucleotide polymorphism genotyping technology, including 68 validated mutations within eight genes (TP53, ARID1A, BRAF, and the PI3K/AKT pathway) previously reported in relation to age. Younger patients were more likely to be female and have poor cell differentiation, diffuse-type tumors, less lymphovascular invasion, fewer liver metastases, and better 5-year overall survival (OS) (68.0% vs. 54.6%, P<0.001) and disease-free survival (DFS) (65.4% vs. 53.0%, P<0.001) rates than older patients. Regarding the genetic alterations, older patients had more microsatellite instability-high (MSI-H) tumors and more ARID1A mutations than younger patients. Younger patients had significantly better OS and DFS rates than older patients for each pathological Tumor, Node, Metastasis (TNM) stage. Older patients had a significantly higher non-cancer related death rate than younger patients (36.2% vs. 12.3%, P<0.001). Age was an independent prognostic factor in GC. In conclusion, age was associated with different clinicopathological features and genetic alterations in GC with curative surgery.

Original languageEnglish
Pages (from-to)18137-18150
Number of pages14
JournalAging
Volume12
Issue number18
DOIs
StatePublished - 30 Sep 2020

Keywords

  • Age
  • Clinicopathological feature
  • Gastric cancer
  • Genetic alteration
  • Prognosis

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