The clinical and electroanatomical characteristics of paroxysmal lone atrial fibrillation

Ta Chuan Tuan, Shih Lin Chang, Yenn Jiang Lin, Yu Feng Hu, Li Wei Lo, Tze Fan Chao, Fa Po Chung, Ching Tai Tai, Shih Ann Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction: Lone atrial fibrillation (AF) is defined as AF occurring in the absence of any other cardiovascular disease. The prognosis of patients with lone AF varies in previous studies, and the clinical and electroanatomical characteristics of lone AF are unclear. The purpose of this study was to investigate the clinical characteristics of lone AF. Methods: This study included 203 patients (52713 years old, 144 males) that underwent circumferential pulmonary vein isolation (CPVI) for paroxysmal AF. The mean voltage and total activation time of the individual atria were obtained by using a NavX mapping system and were compared for patients with lone and non-lone AF. Several parameters, including the age, gender, AF duration, and left atrial (LA) diameter were analyzed. Results: Compared with non-lone AF patients, lone AF patients were significantly younger (49713 years old vs. 58711 years old, p<0.001) and had lower body-mass index (BMI, 24.6072.96 vs. 26.0773.29, p=0.02), lesser cholesterol level (169.06731.41 vs. 183.63731.12, p=0.014), smaller LA diameter (35.8974.90 vs. 40.8674.62, p<0.001), and higher LA bipolar voltage (2.1070.50 vs. 1.8370.73 mV, p<0.05). Furthermore, a dramatic voltage reduction was observed for 60-year-old patients. Conclusion: Patients with lone AF have unique clinical and electroanatomical characteristics.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
Journaljournal of arrhythmia
Issue number3
StatePublished - Jun 2012


  • Lone atrial fibrillation
  • Pulmonary vein isolation
  • Voltage


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