The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG2[Gd(TTDA-BOM)]

Jo Chi Jao; Yun-Ming Wang; Ming Hung Ou; Shih Hsie Chen; Yen Ku Chen; Twei Shiun Jaw; Gin Chung Liu; Po Chou Chen

doi:10.1109/IEMBS.2005.1616756

The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG₂[Gd(TTDA-BOM)]

Jo Chi Jao^*, Yun-Ming Wang, Ming Hung Ou, Shih Hsie Chen, Yen Ku Chen, Twei Shiun Jaw, Gin Chung Liu, Po Chou Chen

^*Corresponding author for this work

Institute of Molecular Medicine and Bioengineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

[Gd(TTDA-BOM)]^2- is a newly developed paramagnetic contrast agent. The ligand, TTDA-BOM, bears a benzyloxymethyl group so that the lipophilicity is increased. The water exchange rate for [Gd(TTDA-BOM)] ^2- is significantly higher than that of [Gd(DTPA)]^2- and [Gd(BOPTA)]^2-. In addition, the bound relaxivity of this Gd (III) complex has a remarkably high value with HSA. Therefore, it has potential to be used as a blood pool contrast agent for MRI. The aim of this study is to investigate the characterization and imaging behavior of NMG ₂[Gd(TTDA-BOM)] in normal rat livers and hearts using a 3T high field whole-body MR scanner. The high field MR scanner is expected to have a higher signal to noise ratio. The relaxivities r₁ and r₂ for [Gd(TTDA-BOM)]^2- at 3T are 5.97 mM^-1 s^-1 and 7.99 mM^-1 s^-1 respectively, which are higher than those for [Gd(DTPA)]² (r₁=4.64 mM^-1 s^-1 and r₂=5.08 mM^-1 s^-1). The dynamic MRI studies show that there is marked enhancement in livers and hearts right after the bolus injection and the enhancement ratios keep high until two hours. In conclusion, [Gd(TTDA-BOM)]^2- might have a good potential in both cardiovascular and hepatobiliary applications.

Original language	English
Title of host publication	Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages	1650-1651
Number of pages	2
DOIs	https://doi.org/10.1109/IEMBS.2005.1616756
State	Published - 2005
Event	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China Duration: 1 Sep 2005 → 4 Sep 2005

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	7 VOLS
ISSN (Print)	0589-1019

Conference

Conference	2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Country/Territory	China
City	Shanghai
Period	1/09/05 → 4/09/05

Keywords

3T
Gd(DTPA)
Gd(TTDA-BOM)
Magnetic resonance imaging
Paramagnetic contrast agent

Access to Document

10.1109/IEMBS.2005.1616756

Cite this

Jao, J. C., Wang, Y.-M., Ou, M. H., Chen, S. H., Chen, Y. K., Jaw, T. S., Liu, G. C., & Chen, P. C. (2005). The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG₂[Gd(TTDA-BOM)]. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 1650-1651). Article 1616756 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS). https://doi.org/10.1109/IEMBS.2005.1616756

Jao, Jo Chi ; Wang, Yun-Ming ; Ou, Ming Hung et al. / The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG₂[Gd(TTDA-BOM)]. Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. pp. 1650-1651 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

@inproceedings{fac9c77dd0a5433785421c11df459609,

title = "The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG2[Gd(TTDA-BOM)]",

abstract = "[Gd(TTDA-BOM)]2- is a newly developed paramagnetic contrast agent. The ligand, TTDA-BOM, bears a benzyloxymethyl group so that the lipophilicity is increased. The water exchange rate for [Gd(TTDA-BOM)] 2- is significantly higher than that of [Gd(DTPA)]2- and [Gd(BOPTA)]2-. In addition, the bound relaxivity of this Gd (III) complex has a remarkably high value with HSA. Therefore, it has potential to be used as a blood pool contrast agent for MRI. The aim of this study is to investigate the characterization and imaging behavior of NMG 2[Gd(TTDA-BOM)] in normal rat livers and hearts using a 3T high field whole-body MR scanner. The high field MR scanner is expected to have a higher signal to noise ratio. The relaxivities r1 and r2 for [Gd(TTDA-BOM)]2- at 3T are 5.97 mM-1 s-1 and 7.99 mM-1 s-1 respectively, which are higher than those for [Gd(DTPA)]2 (r1=4.64 mM-1 s-1 and r2=5.08 mM-1 s-1). The dynamic MRI studies show that there is marked enhancement in livers and hearts right after the bolus injection and the enhancement ratios keep high until two hours. In conclusion, [Gd(TTDA-BOM)]2- might have a good potential in both cardiovascular and hepatobiliary applications.",

keywords = "3T, Gd(DTPA), Gd(TTDA-BOM), Magnetic resonance imaging, Paramagnetic contrast agent",

author = "Jao, {Jo Chi} and Yun-Ming Wang and Ou, {Ming Hung} and Chen, {Shih Hsie} and Chen, {Yen Ku} and Jaw, {Twei Shiun} and Liu, {Gin Chung} and Chen, {Po Chou}",

year = "2005",

doi = "10.1109/IEMBS.2005.1616756",

language = "English",

isbn = "0780387406",

series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

pages = "1650--1651",

booktitle = "Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005",

note = "2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 ; Conference date: 01-09-2005 Through 04-09-2005",

}

Jao, JC, Wang, Y-M, Ou, MH, Chen, SH, Chen, YK, Jaw, TS, Liu, GC & Chen, PC 2005, The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG₂[Gd(TTDA-BOM)]. in Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005., 1616756, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 7 VOLS, pp. 1650-1651, 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, China, 1/09/05. https://doi.org/10.1109/IEMBS.2005.1616756

The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG₂[Gd(TTDA-BOM)]. / Jao, Jo Chi; Wang, Yun-Ming; Ou, Ming Hung et al.
Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 1650-1651 1616756 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Jao, Jo Chi

AU - Wang, Yun-Ming

AU - Ou, Ming Hung

AU - Chen, Shih Hsie

AU - Chen, Yen Ku

AU - Jaw, Twei Shiun

AU - Liu, Gin Chung

AU - Chen, Po Chou

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N2 - [Gd(TTDA-BOM)]2- is a newly developed paramagnetic contrast agent. The ligand, TTDA-BOM, bears a benzyloxymethyl group so that the lipophilicity is increased. The water exchange rate for [Gd(TTDA-BOM)] 2- is significantly higher than that of [Gd(DTPA)]2- and [Gd(BOPTA)]2-. In addition, the bound relaxivity of this Gd (III) complex has a remarkably high value with HSA. Therefore, it has potential to be used as a blood pool contrast agent for MRI. The aim of this study is to investigate the characterization and imaging behavior of NMG 2[Gd(TTDA-BOM)] in normal rat livers and hearts using a 3T high field whole-body MR scanner. The high field MR scanner is expected to have a higher signal to noise ratio. The relaxivities r1 and r2 for [Gd(TTDA-BOM)]2- at 3T are 5.97 mM-1 s-1 and 7.99 mM-1 s-1 respectively, which are higher than those for [Gd(DTPA)]2 (r1=4.64 mM-1 s-1 and r2=5.08 mM-1 s-1). The dynamic MRI studies show that there is marked enhancement in livers and hearts right after the bolus injection and the enhancement ratios keep high until two hours. In conclusion, [Gd(TTDA-BOM)]2- might have a good potential in both cardiovascular and hepatobiliary applications.

AB - [Gd(TTDA-BOM)]2- is a newly developed paramagnetic contrast agent. The ligand, TTDA-BOM, bears a benzyloxymethyl group so that the lipophilicity is increased. The water exchange rate for [Gd(TTDA-BOM)] 2- is significantly higher than that of [Gd(DTPA)]2- and [Gd(BOPTA)]2-. In addition, the bound relaxivity of this Gd (III) complex has a remarkably high value with HSA. Therefore, it has potential to be used as a blood pool contrast agent for MRI. The aim of this study is to investigate the characterization and imaging behavior of NMG 2[Gd(TTDA-BOM)] in normal rat livers and hearts using a 3T high field whole-body MR scanner. The high field MR scanner is expected to have a higher signal to noise ratio. The relaxivities r1 and r2 for [Gd(TTDA-BOM)]2- at 3T are 5.97 mM-1 s-1 and 7.99 mM-1 s-1 respectively, which are higher than those for [Gd(DTPA)]2 (r1=4.64 mM-1 s-1 and r2=5.08 mM-1 s-1). The dynamic MRI studies show that there is marked enhancement in livers and hearts right after the bolus injection and the enhancement ratios keep high until two hours. In conclusion, [Gd(TTDA-BOM)]2- might have a good potential in both cardiovascular and hepatobiliary applications.

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KW - Gd(DTPA)

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M3 - Conference contribution

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Jao JC, Wang YM, Ou MH, Chen SH, Chen YK, Jaw TS et al. The characterization and imaging behavior of a new developed paramagnetic contrast agent NMG₂[Gd(TTDA-BOM)]. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 1650-1651. 1616756. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). doi: 10.1109/IEMBS.2005.1616756