The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer

Chun Yuan Chang, Jyh Der Leu, Yi Jang Lee*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

The actin depolymerizing factor (ADF)/cofilin protein family is essential for actin dynamics, cell division, chemotaxis and tumor metastasis. Cofilin-1 (CFL-1) is a primary non-muscle isoform of the ADF/cofilin protein family accelerating the actin filamental turnover in vitro and in vivo. In response to environmental stimulation, CFL-1 enters the nucleus to regulate the actin dynamics. Although the purpose of this cytoplasm-nucleus transition remains unclear, it is speculated that the interaction between CFL-1 and DNA may influence various biological responses, including DNA damage repair. In this review, we will discuss the possible involvement of CFL-1 in DNA damage responses (DDR) induced by ionizing radiation (IR), and the implications for cancer radiotherapy.

Original languageEnglish
Pages (from-to)4095-4120
Number of pages26
JournalInternational Journal Of Molecular Sciences
Volume16
Issue number2
DOIs
StatePublished - 13 Feb 2015

Keywords

  • Actin cytoskeleton
  • ADF/cofilin
  • DDR
  • Radiosensitivity
  • Radiotherapy

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