TFEB- and TFE3-dependent autophagy activation supports cancer proliferation in the absence of centrosomes

Keyphrases

• Centrosome 100%
• Autophagy Pathway 100%
• Transcription Factor E3 (TFE3) 100%
• Cancer Proliferation 100%
• Polo-like Kinase 4 (PLK4) 57%
• LAMP2 42%
• Cancer Cells 28%
• Tumor Protein p53 (TP53) 28%
• Adenoviral 28%
• ATG5 28%
• STILs 28%
• Treatment Strategy 14%
• Human Cancer 14%
• In Cancer 14%
• Transcriptional Activation 14%
• Therapeutic Strategies 14%
• Luciferase 14%
• Lysosome 14%
• Nuclear Translocation 14%
• Antiproliferative Activity 14%
• Biochemical Analysis 14%
• Nuclear Localization Signal 14%
• Autophagy 14%
• Transcription Factor Binding 14%
• Dephosphorylation 14%
• Enhanced Green Fluorescent Protein (eGFP) 14%
• Autophagosome 14%
• Red Fluorescent Protein 14%
• Acentrosomal 14%
• Microtubule-associated Protein 1 Light Chain 3 14%
• Chloroquine 14%
• MAP1LC3B 14%
• Double Knockout 14%
• Centrosome Amplification 14%
• Cre Recombinase 14%
• LysoTracker Red 14%
• LC3B 14%
• LAMP1 14%
• SAS-6 14%
• 4′,6-diamidino-2-phenylindole 14%
• Transcription Factor EB 14%
• Melanocyte Inducing Transcription Factor 14%
• SASS6 14%

Biochemistry, Genetics and Molecular Biology

• Centrosome 100%
• Autophagy 100%
• TFEB 100%
• TFE3 100%
• Polo-Like Kinase 50%
• Transcription Factors 37%
• Cancer Cell 25%
• P53 25%
• Lysosome 25%
• Synapsin I 25%
• Protein Assembly 25%
• STIL 25%
• Transcription Initiation 12%
• Luciferase 12%
• Transactivation 12%
• Enhancer Region 12%
• Green Fluorescent Protein 12%
• Melanocyte 12%
• Nuclear Localization Sequence 12%
• Dephosphorylation 12%
• Membrane Protein 12%
• Transmembrane Protein 12%
• Light Chain 12%
• Microtubule-Associated Protein 12%
• Nomenclature 12%
• Antiproliferative Activity 12%
• Cre Recombinase 12%
• Microphthalmia-Associated Transcription Factor 12%
• ATG5 12%
• DAPI 12%
• LAMP2 12%
• LAMP1 12%