Taxane-induced peripheral neuropathy: Objective and subjective comparison between paclitaxel and docetaxel in patients with breast cancer

Ya Ning Chan, You Wun Jheng, Pei Ju Wang, Chin Yau Chen, Ming Wei Lin, Ya Jung Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

BACKGROUND: Taxane-induced peripheral neuropathy (TIPN) is caused by the neurotoxicity of paclitaxel and docetaxel, but the differences between paclitaxel- and docetaxel-induced peripheral neuropathy are understudied. OBJECTIVES: The purpose of this study is to compare TIPN between docetaxel and paclitaxel in patients with breast cancer and to examine the consistency of measuring TIPN between researchers and patients. METHODS: Secondary data were analyzed from a cross-sectional study that included 64 patients with breast cancer from two teaching hospitals in Taiwan. Objective and subjective TIPN were measured. FINDINGS: Results indicated significant differences in objective TIPN, sensory sum score, and motor sum score between groups. No significant difference was detected in subjective TIPN between groups.

Original languageEnglish
Pages (from-to)494-501
Number of pages8
JournalClinical Journal of Oncology Nursing
Volume23
Issue number5
DOIs
StatePublished - Oct 2019

Keywords

  • Breast cancer
  • Docetaxel
  • Paclitaxel
  • Taxane-induced peripheral neuropathy

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