Targeted delivery systems for oligonucleotide therapeutics

Bo Yu, Xiaobin Zhao, James L. Lee, Robert J. Lee*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations

Abstract

Oligonucleotides including antisense oligonucleotides and siRNA are emerging as promising therapeutic agents against a variety of diseases. Effective delivery of these molecules is critical to their successful clinical application. Targeted systems can greatly improve the efficiency and specificity of oligonucleotides delivery. Meanwhile, an effective delivery system must successfully overcome a multitude of biological barriers to enable the oligonucleotides to reach the site of action and access their biological targets. Several delivery strategies based on different platform technologies and different targeting ligands have been developed to achieve these objectives. This review aims at providing a summary and perspective on recent progress in this very active area of research.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalAAPS Journal
Volume11
Issue number1
DOIs
StatePublished - Mar 2009

Keywords

  • Chemical modification
  • Liposomes
  • Nonviral vectors
  • RNA interference
  • Small interfering RNA
  • Targeted delivery

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