Systematic mutation analysis of the catechol O-methyltransferase gene as a candidate gene for schizophrenia

Chia Hsiang Chen*, Yu Ru Lee, Ming Yi Chung, Fu Chuan Wei, Farn Jong Koong, Cheng Kuang Shaw, Jih I. Yeh, Kwang Jen Hsiao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Objective: Catechol O-methyltransferase (COMT) is involved in the degradation of catecholamine neurotransmitters. Recent linkage studies of schizophrenia and molecular studies of velocardiofacial syndrome suggest that the COMT gene might be a candidate gene for schizophrenia. Method: The authors systematically searched for mutations and microdeletion of the COMT gene in 177 Chinese schizophrenic patients from Taiwan; 99 comparison subjects were also studied. Results: Five molecular variants were identified: c.186C>T at exon 3, c.408C>G at exon 4, c.472G>A at exon 4, c.597G>A at exon 5, and c.821-827insC at the 3' untranslated region. However, no differences in the genotype and haplotype frequencies of these molecular variants between the schizophrenic and comparison subjects were detected. Furthermore, no microdeletion was identified among the patients. Conclusions: These data suggest that the COMT gene does not play a major role in the pathogenesis of schizophrenia, and the genotypic overlap between schizophrenia and velocardiofacial syndrome was rare in this cohort.

Original languageEnglish
Pages (from-to)1273-1275
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number8
StatePublished - Aug 1999


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