Synthesis, surface modification, and photophysical studies of Ln2O2S:Ln'3+ (Ln=Gd, Tb, Eu; Ln'=Tb and/ or Eu) nanoparticles for luminescence bioimaging

Syue Liang Lin, Tse Ying Liu, Chun Liang Lo, Bo Sheng Wang, Yi Jang Lee, Kai Ying Lin, C. Allen Chang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

It has been demonstrated that by using doping and co-doping strategies the lifetimes as well as luminescence intensities of the doping species in the lanthanide oxysulfide nanoparticles (NPs) Ln2O2S:Ln'3+ (Ln=Gd, Tb, Eu; Ln'=Tb, Eu, 1% and 5%) could be tuned. The lanthanide oxysulfide NPs, i.e., Gd2O2S, Tb2O2S and Gd2O2S:Tb3+(5%) were synthesized as matrices and doped with Eu3+(1% or 5%), by the thermal decomposition method and characterized by TEM, XRD, photoluminescence, cellular and in vivo animal imaging studies for potential luminescence bioimaging applications. Of these materials, Gd2O2S:Eu3+(5%) NPs possess the highest photo-stability and strongest luminescent intensity at 625 nm with a lifetime 853 μs in hexane. Surface modification of the Gd2O2S:Eu3+(5%) NPs with mPEG-APTES to increase its aqueous solubility resulted in almost complete luminescence quenching. Calcination of the host Gd2O2S:Eu3+(5%) NPs at 400 °C to increase their crystallinity and maintained some of their luminescence properties in aqueous solution. Further surface modification of the Gd2O2S:Eu3+(5%)-APTES NPs with mPEG and Alexa Fluor 660 allowed their effective cellular and in vivo animal luminescence imaging with low bio-toxicity. These novel imaging materials with tunable lifetimes would be potentially useful for luminescence bioimaging applications, particularly in the time-resolved, up-conversion, and/or multiplex modes.

Original languageEnglish
Pages (from-to)165-175
Number of pages11
JournalJournal of Luminescence
Volume175
DOIs
StatePublished - 1 Jul 2016

Keywords

  • Cytotoxicity
  • Imaging
  • Lanthanide oxysulfide nanoparticles
  • Lifetime
  • Photoluminescence

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