Synthesis and characterization of PEG-PCL-PEG Triblock copolymers as carriers of doxorubicin for the treatment of breast cancer

Nguyen Van Cuong; Ming Fa Hsieh; Yung Tsung Chen; Ian Liau

doi:10.1002/app.32266

Synthesis and characterization of PEG-PCL-PEG Triblock copolymers as carriers of doxorubicin for the treatment of breast cancer

Nguyen Van Cuong, Ming Fa Hsieh^*, Yung Tsung Chen, Ian Liau

^*Corresponding author for this work

Institute of Molecular science

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Triblock copolymers of monomethoxy poly(ethylene glycol) (mPEG) and ε-caprolactone (CL) were prepared with varying lengths of poly(ε-caprolactone) (PCL) compositions and a fixed length of mPEG segment. The molecular characteristics of triblock copolymers were characterized by ¹H NMR, gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). These amphiphilic linear copolymers based on PCL hydrophobic chain and hydrophilic mPEG ending, which can self-assemble into nanoscopic micelles with their hydrophobic cores, encapsulated doxorubicin (DOX) in an aqueous solution. The particle size of prepared micelles was around 40-92 nm. The DOX loading content and DOX loading efficiency were from 3.7-7.4% to 26-49%, respectively. DOX-released profile was pH-dependent and faster at pH 5.4 than pH 7.4. Additionally, the cytotoxicity of DOX-loaded micelles was found to be similar with free DOX in drugresistant cells (MCF-7/adr). The great amounts of DOX and fast uptake accumulated into the MCF-7/adr cells from DOX-loaded micelles suggest a potential application in cancer chemotherapy.

Original language	English
Pages (from-to)	3694-3703
Number of pages	10
Journal	Journal of Applied Polymer Science
Volume	117
Issue number	6
DOIs	https://doi.org/10.1002/app.32266
State	Published - 15 Sep 2010

Keywords

Drug delivery systems
Micelles
Monomethoxy poly(ethylene glycol)
Multidrug resistance
Nanoparticles
Poly(ε-caprolactone)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/app.32266

Cite this

@article{301b46e50cdb428dafaee4be2a51df95,

title = "Synthesis and characterization of PEG-PCL-PEG Triblock copolymers as carriers of doxorubicin for the treatment of breast cancer",

abstract = "Triblock copolymers of monomethoxy poly(ethylene glycol) (mPEG) and ε-caprolactone (CL) were prepared with varying lengths of poly(ε-caprolactone) (PCL) compositions and a fixed length of mPEG segment. The molecular characteristics of triblock copolymers were characterized by 1H NMR, gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). These amphiphilic linear copolymers based on PCL hydrophobic chain and hydrophilic mPEG ending, which can self-assemble into nanoscopic micelles with their hydrophobic cores, encapsulated doxorubicin (DOX) in an aqueous solution. The particle size of prepared micelles was around 40-92 nm. The DOX loading content and DOX loading efficiency were from 3.7-7.4% to 26-49%, respectively. DOX-released profile was pH-dependent and faster at pH 5.4 than pH 7.4. Additionally, the cytotoxicity of DOX-loaded micelles was found to be similar with free DOX in drugresistant cells (MCF-7/adr). The great amounts of DOX and fast uptake accumulated into the MCF-7/adr cells from DOX-loaded micelles suggest a potential application in cancer chemotherapy.",

keywords = "Drug delivery systems, Micelles, Monomethoxy poly(ethylene glycol), Multidrug resistance, Nanoparticles, Poly(ε-caprolactone)",

author = "Cuong, {Nguyen Van} and Hsieh, {Ming Fa} and Chen, {Yung Tsung} and Ian Liau",

year = "2010",

month = sep,

day = "15",

doi = "10.1002/app.32266",

language = "English",

volume = "117",

pages = "3694--3703",

journal = "Journal of Applied Polymer Science",

issn = "0021-8995",

publisher = "John Wiley & Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Synthesis and characterization of PEG-PCL-PEG Triblock copolymers as carriers of doxorubicin for the treatment of breast cancer

AU - Cuong, Nguyen Van

AU - Hsieh, Ming Fa

AU - Chen, Yung Tsung

AU - Liau, Ian

PY - 2010/9/15

Y1 - 2010/9/15

N2 - Triblock copolymers of monomethoxy poly(ethylene glycol) (mPEG) and ε-caprolactone (CL) were prepared with varying lengths of poly(ε-caprolactone) (PCL) compositions and a fixed length of mPEG segment. The molecular characteristics of triblock copolymers were characterized by 1H NMR, gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). These amphiphilic linear copolymers based on PCL hydrophobic chain and hydrophilic mPEG ending, which can self-assemble into nanoscopic micelles with their hydrophobic cores, encapsulated doxorubicin (DOX) in an aqueous solution. The particle size of prepared micelles was around 40-92 nm. The DOX loading content and DOX loading efficiency were from 3.7-7.4% to 26-49%, respectively. DOX-released profile was pH-dependent and faster at pH 5.4 than pH 7.4. Additionally, the cytotoxicity of DOX-loaded micelles was found to be similar with free DOX in drugresistant cells (MCF-7/adr). The great amounts of DOX and fast uptake accumulated into the MCF-7/adr cells from DOX-loaded micelles suggest a potential application in cancer chemotherapy.

AB - Triblock copolymers of monomethoxy poly(ethylene glycol) (mPEG) and ε-caprolactone (CL) were prepared with varying lengths of poly(ε-caprolactone) (PCL) compositions and a fixed length of mPEG segment. The molecular characteristics of triblock copolymers were characterized by 1H NMR, gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). These amphiphilic linear copolymers based on PCL hydrophobic chain and hydrophilic mPEG ending, which can self-assemble into nanoscopic micelles with their hydrophobic cores, encapsulated doxorubicin (DOX) in an aqueous solution. The particle size of prepared micelles was around 40-92 nm. The DOX loading content and DOX loading efficiency were from 3.7-7.4% to 26-49%, respectively. DOX-released profile was pH-dependent and faster at pH 5.4 than pH 7.4. Additionally, the cytotoxicity of DOX-loaded micelles was found to be similar with free DOX in drugresistant cells (MCF-7/adr). The great amounts of DOX and fast uptake accumulated into the MCF-7/adr cells from DOX-loaded micelles suggest a potential application in cancer chemotherapy.

KW - Drug delivery systems

KW - Micelles

KW - Monomethoxy poly(ethylene glycol)

KW - Multidrug resistance

KW - Nanoparticles

KW - Poly(ε-caprolactone)

UR - http://www.scopus.com/inward/record.url?scp=77955942377&partnerID=8YFLogxK

U2 - 10.1002/app.32266

DO - 10.1002/app.32266

M3 - Article

AN - SCOPUS:77955942377

SN - 0021-8995

VL - 117

SP - 3694

EP - 3703

JO - Journal of Applied Polymer Science

JF - Journal of Applied Polymer Science

IS - 6

ER -

Synthesis and characterization of PEG-PCL-PEG Triblock copolymers as carriers of doxorubicin for the treatment of breast cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this