Synchronous and Metachronous Colorectal Cancers: Distinct Disease Entities or Different Disease Courses?

Chih Sheng Huang; Shung Haur Yang; Chun Chi Lin; Yuan Tsiu Lan; Shin Ching Chang; Huann Sheng Wang; Wei Shone Chen; Tzu Chen Lin; Jen Kou Lin; Jeng Kai Jiang

Synchronous and Metachronous Colorectal Cancers: Distinct Disease Entities or Different Disease Courses?

Chih Sheng Huang, Shung Haur Yang, Chun Chi Lin, Yuan Tsiu Lan, Shin Ching Chang, Huann Sheng Wang, Wei Shone Chen, Tzu Chen Lin, Jen Kou Lin, Jeng Kai Jiang

Department of Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

BACKGROUND/AIMS: This study aimed to investigate the clinicopathological characteristics of synchronous and metachronous colorectal cancers (CRCs).

METHODOLOGY: From January 1, 2001 to December 31, 2010, 5898 patients who underwent surgical resection for CRCs were enrolled. Synchronous CRC was defined as presence of more than one primary CRC within 6 months of resection of the primary tumor; while CRC that occurred at least 6 months later was regarded as metachronous CRC.

RESULTS: 5346 patients were eligible for the study and divided into three groups: solitary, synchronous and metachronous CRC. The overall prevalence of the synchronous CRC was 2.2% and the 10-year cumulative incidence of metachronous cancer was 0.84%. 29 (64%) metachronous cancers were diagnosed within 3 years of the index cancer and the mean time interval was 3.2 years. Male gender and presence of associated adenoma were significant risk factors for both synchronous and metachronous CRC. Synchronous and metachronous CRC patients shared similar clinicopathological features except that the former were older than the latter by 3.7 years. The five-year survival rates were not different among the three groups.

CONCLUSIONS: Our study indicates that synchronous and metachronous CRC might represent similar disease entity with different courses.

Original language	English
Pages (from-to)	838-842
Number of pages	5
Journal	Hepato-Gastroenterology
Volume	62
Issue number	140
State	Published - 1 Jun 2015

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@article{9e6e8468912741daafe927b49d200775,

title = "Synchronous and Metachronous Colorectal Cancers: Distinct Disease Entities or Different Disease Courses?",

abstract = "BACKGROUND/AIMS: This study aimed to investigate the clinicopathological characteristics of synchronous and metachronous colorectal cancers (CRCs).METHODOLOGY: From January 1, 2001 to December 31, 2010, 5898 patients who underwent surgical resection for CRCs were enrolled. Synchronous CRC was defined as presence of more than one primary CRC within 6 months of resection of the primary tumor; while CRC that occurred at least 6 months later was regarded as metachronous CRC.RESULTS: 5346 patients were eligible for the study and divided into three groups: solitary, synchronous and metachronous CRC. The overall prevalence of the synchronous CRC was 2.2% and the 10-year cumulative incidence of metachronous cancer was 0.84%. 29 (64%) metachronous cancers were diagnosed within 3 years of the index cancer and the mean time interval was 3.2 years. Male gender and presence of associated adenoma were significant risk factors for both synchronous and metachronous CRC. Synchronous and metachronous CRC patients shared similar clinicopathological features except that the former were older than the latter by 3.7 years. The five-year survival rates were not different among the three groups.CONCLUSIONS: Our study indicates that synchronous and metachronous CRC might represent similar disease entity with different courses.",

author = "Huang, {Chih Sheng} and Yang, {Shung Haur} and Lin, {Chun Chi} and Lan, {Yuan Tsiu} and Chang, {Shin Ching} and Wang, {Huann Sheng} and Chen, {Wei Shone} and Lin, {Tzu Chen} and Lin, {Jen Kou} and Jiang, {Jeng Kai}",

year = "2015",

month = jun,

day = "1",

language = "English",

volume = "62",

pages = "838--842",

journal = "Hepato-Gastroenterology",

issn = "0172-6390",

publisher = "H.G.E. Update Medical Publishing Ltd.",

number = "140",

}

TY - JOUR

T1 - Synchronous and Metachronous Colorectal Cancers

T2 - Distinct Disease Entities or Different Disease Courses?

AU - Huang, Chih Sheng

AU - Yang, Shung Haur

AU - Lin, Chun Chi

AU - Lan, Yuan Tsiu

AU - Chang, Shin Ching

AU - Wang, Huann Sheng

AU - Chen, Wei Shone

AU - Lin, Tzu Chen

AU - Lin, Jen Kou

AU - Jiang, Jeng Kai

PY - 2015/6/1

Y1 - 2015/6/1

N2 - BACKGROUND/AIMS: This study aimed to investigate the clinicopathological characteristics of synchronous and metachronous colorectal cancers (CRCs).METHODOLOGY: From January 1, 2001 to December 31, 2010, 5898 patients who underwent surgical resection for CRCs were enrolled. Synchronous CRC was defined as presence of more than one primary CRC within 6 months of resection of the primary tumor; while CRC that occurred at least 6 months later was regarded as metachronous CRC.RESULTS: 5346 patients were eligible for the study and divided into three groups: solitary, synchronous and metachronous CRC. The overall prevalence of the synchronous CRC was 2.2% and the 10-year cumulative incidence of metachronous cancer was 0.84%. 29 (64%) metachronous cancers were diagnosed within 3 years of the index cancer and the mean time interval was 3.2 years. Male gender and presence of associated adenoma were significant risk factors for both synchronous and metachronous CRC. Synchronous and metachronous CRC patients shared similar clinicopathological features except that the former were older than the latter by 3.7 years. The five-year survival rates were not different among the three groups.CONCLUSIONS: Our study indicates that synchronous and metachronous CRC might represent similar disease entity with different courses.

AB - BACKGROUND/AIMS: This study aimed to investigate the clinicopathological characteristics of synchronous and metachronous colorectal cancers (CRCs).METHODOLOGY: From January 1, 2001 to December 31, 2010, 5898 patients who underwent surgical resection for CRCs were enrolled. Synchronous CRC was defined as presence of more than one primary CRC within 6 months of resection of the primary tumor; while CRC that occurred at least 6 months later was regarded as metachronous CRC.RESULTS: 5346 patients were eligible for the study and divided into three groups: solitary, synchronous and metachronous CRC. The overall prevalence of the synchronous CRC was 2.2% and the 10-year cumulative incidence of metachronous cancer was 0.84%. 29 (64%) metachronous cancers were diagnosed within 3 years of the index cancer and the mean time interval was 3.2 years. Male gender and presence of associated adenoma were significant risk factors for both synchronous and metachronous CRC. Synchronous and metachronous CRC patients shared similar clinicopathological features except that the former were older than the latter by 3.7 years. The five-year survival rates were not different among the three groups.CONCLUSIONS: Our study indicates that synchronous and metachronous CRC might represent similar disease entity with different courses.

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M3 - Article

C2 - 26902012

AN - SCOPUS:84979859295

SN - 0172-6390

VL - 62

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JO - Hepato-Gastroenterology

JF - Hepato-Gastroenterology

IS - 140

ER -

Synchronous and Metachronous Colorectal Cancers: Distinct Disease Entities or Different Disease Courses?

Abstract

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